Uterine Transcriptome: Understanding Physiology and Disease Processes.
RNA sequencing
endometriosis
fibroids
leiomyomas
mRNA
microRNA
transcriptomics
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
21 Apr 2023
21 Apr 2023
Historique:
received:
14
02
2023
revised:
16
04
2023
accepted:
20
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
In recent years, transcriptomics has enabled us to gain a deeper understanding of fundamental reproductive physiology, including the menstrual cycle, through a more precise molecular analysis. The endometrial mRNA transcript levels fluctuate during the normal menstrual cycle, indicating changes in the relative recruitment and abundance of inflammatory cells, as well as changes in the receptivity and remodeling of the endometrium. In addition to providing a more comprehensive understanding of the molecular underpinnings of pathological gynecological conditions such as endometriosis, leiomyomas, and adenomyosis through RNA sequencing, this has allowed researchers to create transcriptome profiles during both normal menstrual cycles and pathological gynecological conditions. Such insights could potentially lead to more targeted and personalized therapies for benign gynecological conditions. Here, we provide an overview of recent advances in transcriptome analysis of normal and pathological endometrium.
Identifiants
pubmed: 37106834
pii: biology12040634
doi: 10.3390/biology12040634
pmc: PMC10136129
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH HHS
ID : R01HD094380
Pays : United States
Références
Nature. 2018 Nov;563(7731):347-353
pubmed: 30429548
Semin Reprod Med. 2007 Nov;25(6):437-44
pubmed: 17960528
Gynecol Endocrinol. 2006 Feb;22(2):106-9
pubmed: 16603437
Mol Hum Reprod. 2003 Apr;9(4):189-98
pubmed: 12651900
Biomolecules. 2020 Sep 11;10(9):
pubmed: 32933042
Gynecol Obstet Invest. 2004;58(1):14-8
pubmed: 15004438
PLoS One. 2022 May 31;17(5):e0268793
pubmed: 35639702
Int J Dev Biol. 2014;58(2-4):127-37
pubmed: 25023678
Mol Hum Reprod. 2023 Apr 3;29(4):
pubmed: 36821428
Hum Reprod Update. 2011 Sep-Oct;17(5):637-53
pubmed: 21672902
Best Pract Res Clin Obstet Gynaecol. 2008 Aug;22(4):643-54
pubmed: 18375184
Reprod Sci. 2021 Nov;28(11):3081-3084
pubmed: 34231176
Mol Hum Reprod. 2010 Mar;16(3):178-87
pubmed: 19933690
Biol Reprod. 2017 Oct 1;97(4):564-576
pubmed: 29025102
Cell Mol Life Sci. 2005 Jan;62(2):239-50
pubmed: 15666095
Elife. 2021 Sep 06;10:
pubmed: 34487490
Nature. 2015 Sep 10;525(7568):251-5
pubmed: 26287467
Gynecol Obstet Invest. 2006;62(3):148-59
pubmed: 16679773
Front Physiol. 2022 Apr 27;13:841437
pubmed: 35574479
Expert Rev Mol Diagn. 2015;15(8):999-1010
pubmed: 26051307
PLoS One. 2022 Sep 29;17(9):e0274879
pubmed: 36174000
Hum Reprod. 2019 Dec 1;34(12):2381-2390
pubmed: 31796963
Endocrinology. 2007 Aug;148(8):3814-26
pubmed: 17510236
Hum Reprod. 2009 Oct;24(10):2541-8
pubmed: 19542175
Nat Biotechnol. 2015 Feb;33(2):155-60
pubmed: 25599176
PLoS One. 2017 Dec 7;12(12):e0189159
pubmed: 29216287
Stem Cell Res Ther. 2019 Jan 3;10(1):1
pubmed: 30606242
Reprod Sci. 2012 Oct;19(10):1138-45
pubmed: 22623515
Hum Reprod. 2012 Jul;27(7):2020-9
pubmed: 22556377
Rev Endocr Metab Disord. 2012 Dec;13(4):235-51
pubmed: 22847235
Mol Cancer. 2011 Oct 31;10:132
pubmed: 22040021
Hum Reprod. 1996 Oct;11 Suppl 2:124-33
pubmed: 8982754
Hum Reprod Update. 2014 Jan-Feb;20(1):12-28
pubmed: 24082038
Reprod Biol Endocrinol. 2022 Jul 27;20(1):108
pubmed: 35897028
Fertil Steril. 2010 Apr;93(6):2027-34
pubmed: 18555231
Mol Hum Reprod. 2004 Dec;10(12):879-93
pubmed: 15501903
Fertil Steril. 2016 Sep 1;106(3):766-72
pubmed: 27233758
Mol Cancer. 2015 Sep 22;14:173
pubmed: 26395571
Int J Mol Sci. 2022 Sep 29;23(19):
pubmed: 36232817
Clin Exp Immunol. 1999 Sep;117(3):540-9
pubmed: 10469060
Biochim Biophys Acta. 2012 Dec;1822(12):1931-42
pubmed: 22634130
Autoimmun Rev. 2012 May;11(6-7):A486-92
pubmed: 22155200
Fertil Steril. 2023 Feb;119(2):229-238
pubmed: 36414088
Immunol Invest. 2022 Jul;51(5):1170-1181
pubmed: 33902382
J Soc Gynecol Investig. 1997 May-Jun;4(3):160-6
pubmed: 9258881
Hum Reprod. 2008 Apr;23(4):944-51
pubmed: 18281245
Fertil Steril. 2016 Nov;106(6):1420-1431.e7
pubmed: 27475412
Hum Reprod. 2015 Sep;30(9):2014-21
pubmed: 26202914
JBRA Assist Reprod. 2021 Apr 27;25(2):303-309
pubmed: 33656838
Front Cell Dev Biol. 2020 Jul 09;8:497
pubmed: 32742977
Development. 1998 Aug;125(16):3201-11
pubmed: 9671592
Nat Genet. 2021 Dec;53(12):1698-1711
pubmed: 34857954
Cell Biosci. 2021 Mar 8;11(1):51
pubmed: 33685511
Commun Biol. 2020 Jan 21;3(1):37
pubmed: 31965050
Am J Reprod Immunol. 1991 Dec;26(4):137-42
pubmed: 1840727
Fertil Steril. 2003 Dec;80(6):1488-94
pubmed: 14667888
J Gynecol Obstet Hum Reprod. 2021 Dec;50(10):102228
pubmed: 34520877
Reprod Biomed Online. 2023 Jan;46(1):99-106
pubmed: 36229390
Int J Mol Sci. 2018 Aug 25;19(9):
pubmed: 30149651
Nat Med. 2020 Oct;26(10):1644-1653
pubmed: 32929266
Fertil Steril. 2009 Mar;91(3):687-93
pubmed: 18314120
Hum Reprod Update. 1996 Jan-Feb;2(1):57-62
pubmed: 9079403
Reprod Fertil Dev. 2019 Apr;31(4):645-657
pubmed: 30428300
Nat Cell Biol. 2022 Aug;24(8):1306-1318
pubmed: 35864314
Reprod Biol Endocrinol. 2016 Sep 20;14(1):60
pubmed: 27645154
Obstet Gynecol. 2003 Mar;101(3):431-7
pubmed: 12636944
J Reprod Immunol. 2020 Jun;139:103105
pubmed: 32199194
Biol Reprod. 2022 Jan 13;106(1):155-172
pubmed: 34591094
Biomed Pharmacother. 2015 Apr;71:1-6
pubmed: 25960207
Hum Reprod Update. 2014 Sep-Oct;20(5):670-87
pubmed: 24706045
Hum Reprod. 1996 Oct;11 Suppl 2:95-108
pubmed: 8982751
Am J Obstet Gynecol. 2006 Aug;195(2):406.e1-16
pubmed: 16890550
Fertil Steril. 2009 Apr;91(4):1215-23
pubmed: 18339376
Biol Reprod. 2021 Jul 2;105(1):7-31
pubmed: 33739368
Gynecol Endocrinol. 2016 Sep;32(9):696-700
pubmed: 27379972
Female Pelvic Med Reconstr Surg. 2021 Feb 1;27(2):e481-e483
pubmed: 33105342
Clin Epigenetics. 2021 May 25;13(1):116
pubmed: 34034824
Fertil Steril. 2008 Feb;89(2):301-10
pubmed: 17678915
F S Sci. 2022 Aug;3(3):279-287
pubmed: 35697654
Endocrinology. 2003 Jul;144(7):2870-81
pubmed: 12810542
J Immunol. 2007 Feb 15;178(4):2572-8
pubmed: 17277167
Hum Reprod. 2016 Apr;31(4):844-53
pubmed: 26874359
Biomed Rep. 2017 Jun;6(6):654-662
pubmed: 28584637
J Exp Med. 1999 Nov 15;190(10):1505-16
pubmed: 10562324
Hum Reprod Open. 2021 Apr 14;2021(2):hoab011
pubmed: 33880420
Fertil Steril. 2005 Oct;84 Suppl 2:1180-90
pubmed: 16210010
Nat Commun. 2017 Aug 9;8(1):224
pubmed: 28794456
Cell Mol Immunol. 2020 Nov;17(11):1204-1207
pubmed: 32678309
Biol Reprod. 2017 Jan 1;96(1):24-33
pubmed: 28395321
Fertil Steril. 2007 Apr;87(4):725-36
pubmed: 17430732
Hum Reprod. 2008 Feb;23(2):340-51
pubmed: 18077318
Fertil Steril. 2013 Jan;99(1):256-263.e3
pubmed: 23043685