Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme.
drug discovery
kinetic studies
redox enzymes
xanthine oxidase
xanthine oxidase inhibitors
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
28 Mar 2023
28 Mar 2023
Historique:
received:
02
03
2023
revised:
22
03
2023
accepted:
24
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species. Altered functions of XO may lead to severe pathological diseases, including gout-causing hyperuricemia and oxidative damage of tissues. These findings prompted research studies aimed at targeting the activity of this crucial enzyme. During the course of a virtual screening study aimed at the discovery of novel inhibitors targeting another oxidoreductase, superoxide dismutase, we identified four compounds with non-purine-like structures, namely
Identifiants
pubmed: 37107199
pii: antiox12040825
doi: 10.3390/antiox12040825
pmc: PMC10135315
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : MUR (Italy), promotion and policy development fund of the National Research Programme (PNR)-DM737 of 25-06-2021
ID : CUP I55F21003620001
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