The Current Status of DNA-Repair-Directed Precision Oncology Strategies in Epithelial Ovarian Cancers.
BRCA
DNA repair
PARPi
ovarian cancer
precision oncology
synthetic lethality
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Apr 2023
14 Apr 2023
Historique:
received:
16
03
2023
revised:
10
04
2023
accepted:
12
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Survival outcomes for patients with advanced ovarian cancer remain poor despite advances in chemotherapy and surgery. Platinum-based systemic chemotherapy can result in a response rate of up to 80%, but most patients will have recurrence and die from the disease. Recently, the DNA-repair-directed precision oncology strategy has generated hope for patients. The clinical use of poly(ADP-ribose) polymerase (PARP) inhibitors in BRCA germ-line-deficient and/or platinum-sensitive epithelial ovarian cancers has improved survival. However, the emergence of resistance is an ongoing clinical challenge. Here, we review the current clinical state of PARP inhibitors and other clinically viable targeted approaches in epithelial ovarian cancers.
Identifiants
pubmed: 37108451
pii: ijms24087293
doi: 10.3390/ijms24087293
pmc: PMC10138422
pii:
doi:
Substances chimiques
Poly(ADP-ribose) Polymerase Inhibitors
0
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Naaz Coker Ovarian Cancer Fellowship, University of Nottingham
ID : n/a
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