Epigenetic Gene-Regulatory Loci in Alu Elements Associated with Autism Susceptibility in the Prefrontal Cortex of ASD.

Humans Autistic Disorder / genetics Autism Spectrum Disorder / genetics Alu Elements / genetics DNA Transposable Elements DNA Methylation Epigenesis, Genetic Prefrontal Cortex / metabolism
Alu elements DNA methylation autism spectrum disorder epigenetic mechanism retrotransposons transposable elements

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Apr 2023
Historique:
received: 24 02 2023
revised: 07 04 2023
accepted: 17 04 2023
medline: 1 5 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

Alu elements are transposable elements that can influence gene regulation through several mechanisms; nevertheless, it remains unclear whether dysregulation of Alu elements contributes to the neuropathology of autism spectrum disorder (ASD). In this study, we characterized transposable element expression profiles and their sequence characteristics in the prefrontal cortex tissues of ASD and unaffected individuals using RNA-sequencing data. Our results showed that most of the differentially expressed transposable elements belong to the Alu family, with 659 loci of Alu elements corresponding to 456 differentially expressed genes in the prefrontal cortex of ASD individuals. We predicted cis- and trans-regulation of Alu elements to host/distant genes by conducting correlation analyses. The expression level of Alu elements correlated significantly with 133 host genes (cis-regulation, adjusted

Identifiants

DOI: 10.3390/ijms24087518 PMID: 37108679 PMC: PMC10139202
pubmed: 37108679
pii: ijms24087518
doi: 10.3390/ijms24087518
pmc: PMC10139202
pii:
doi:

Substances chimiques

DNA Transposable Elements 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ratchadapisek Somphot Fund for Supporting Research Unit, Chulalongkorn University
ID : GRU 6300437001-1, GRU_64_033_37_004, and GRU 6506537004-1
Organisme : Thailand Science research and Innovation Fund Chulalongkorn University
ID : HEA663700091
Organisme : the Second Century Fund (C2F), Chulalongkorn University
ID : NA
Organisme : The 90th Anniversary Chulalongkorn University Fund Ratchadaphiseksomphot Endowment Fund, Graduate School, Chulalongkorn University
ID : GCUGR1125651061D-061
Organisme : National Research Council of Thailand (NRCT)
ID : NA
Organisme : The Scholarship from the Graduate School, Chulalongkorn University to commemorate the 72nd anniversary of his Majesty King Bhumibol Aduladej
ID : NA
Organisme : the Royal Golden Jubilee Ph.D. Program Scholarship from the Thai-land Research Fund and National Research Council of Thailand
ID : PHD/0029/2561
Organisme : The 90th Anniversary Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund:), Graduate School, Chulalongkorn University
ID : GCUGR1125632108D-108

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Auteurs

Thanit Saeliw (T)

The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Songphon Kanlayaprasit (S)

Systems Neuroscience of Autism and Psychiatric Disorders (SYNAPS) Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Surangrat Thongkorn (S)

The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Biotechnology and Biomedicine (DTU Bioengineering), Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

Kwanjira Songsritaya (K)

The M.Sc. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Bumpenporn Sanannam (B)

Division of Anatomy, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.

Chanachai Sae-Lee (C)

Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Depicha Jindatip (D)

Systems Neuroscience of Autism and Psychiatric Disorders (SYNAPS) Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
ORCID: 0000-0001-9825-2692

Valerie W Hu (VW)

Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA.
ORCID: 0000-0002-3357-0777

Tewarit Sarachana (T)

Systems Neuroscience of Autism and Psychiatric Disorders (SYNAPS) Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
ORCID: 0000-0003-4518-9399

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Rétroéléments › Éléments SINE › Séquences Alu › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › Éléments transposables d'ADN › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic Gene-Regulatory Loci in Alu...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › Epigenetic Gene-Regulatory Loci in Alu...