In Silico Design of a Chimeric Humanized L-asparaginase.
L-asparaginase
acute lymphoblastic leukemia
chimeric
immunogenicity
in silico
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Apr 2023
20 Apr 2023
Historique:
received:
03
02
2023
revised:
13
04
2023
accepted:
15
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Acute lymphoblastic leukemia (ALL) is the most common cancer among children worldwide, characterized by an overproduction of undifferentiated lymphoblasts in the bone marrow. The treatment of choice for this disease is the enzyme L-asparaginase (ASNase) from bacterial sources. ASNase hydrolyzes circulating L-asparagine in plasma, leading to starvation of leukemic cells. The ASNase formulations of
Identifiants
pubmed: 37108713
pii: ijms24087550
doi: 10.3390/ijms24087550
pmc: PMC10144303
pii:
doi:
Substances chimiques
Asparaginase
EC 3.5.1.1
Asparagine
7006-34-0
Recombinant Fusion Proteins
0
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : São Paulo Research Foundation
ID : 2016/22065-5
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