Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes.
cardiac masses
cardio-oncology
echocardiography
gender medicine
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
19 Apr 2023
19 Apr 2023
Historique:
received:
10
02
2023
revised:
09
04
2023
accepted:
16
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Cardiac masses (CM) represent a heterogeneous clinical scenario, and sex-related differences of these patients remain to be established. To evaluate sex-related disparities in CMs regarding clinical presentation and outcomes. The study cohort included 321 consecutive patients with CM enrolled in our Centre between 2004 and 2022. A definitive diagnosis was achieved by histological examination or, in the case of cardiac thrombi, with radiological evidence of thrombus resolution after anticoagulant treatment. All-cause mortality at follow-up was evaluated. Multivariable regression analysis assessed the potential prognostic disparities between men and women. Out of 321 patients with CM, 172 (54%) were female. Women were more frequently younger ( In a large cohort of cardiac masses, a significant sex-related difference in histotype prevalence was found: Benign CMs affected female patients more frequently, while malignant tumours affected predominantly men. Despite better overall survival in women, sex did not influence prognosis in benign and malignant masses.
Sections du résumé
BACKGROUND
BACKGROUND
Cardiac masses (CM) represent a heterogeneous clinical scenario, and sex-related differences of these patients remain to be established.
PURPOSE
OBJECTIVE
To evaluate sex-related disparities in CMs regarding clinical presentation and outcomes.
MATERIAL AND METHODS
METHODS
The study cohort included 321 consecutive patients with CM enrolled in our Centre between 2004 and 2022. A definitive diagnosis was achieved by histological examination or, in the case of cardiac thrombi, with radiological evidence of thrombus resolution after anticoagulant treatment. All-cause mortality at follow-up was evaluated. Multivariable regression analysis assessed the potential prognostic disparities between men and women.
RESULTS
RESULTS
Out of 321 patients with CM, 172 (54%) were female. Women were more frequently younger (
CONCLUSIONS
CONCLUSIONS
In a large cohort of cardiac masses, a significant sex-related difference in histotype prevalence was found: Benign CMs affected female patients more frequently, while malignant tumours affected predominantly men. Despite better overall survival in women, sex did not influence prognosis in benign and malignant masses.
Identifiants
pubmed: 37109293
pii: jcm12082958
doi: 10.3390/jcm12082958
pmc: PMC10142943
pii:
doi:
Types de publication
Journal Article
Langues
eng
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