Evolution of Gold and Iron Oxide Nanoparticles in Conjugates with Methotrexate: Synthesis and Anticancer Effects.
X-ray photoelectron spectroscopy
X-ray small-angle scattering
anticancer drug
drug conjugates
gold nanoparticles
iron oxide nanoparticles
metal-vapor synthesis
methotrexate
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
19 Apr 2023
19 Apr 2023
Historique:
received:
10
03
2023
revised:
02
04
2023
accepted:
17
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Au and Fe nanoparticles and their conjugates with the drug methotrexate were obtained by an environmentally safe method of metal-vapor synthesis (MVS). The materials were characterized by transmission and scanning electron microscopy (TEM, SEM), X-ray photoelectron spectroscopy (XPS), and small-angle X-ray scattering using synchrotron radiation (SAXS). The use of acetone as an organic reagent in the MVS makes it possible to obtain Au and Fe particles with an average size of 8.3 and 1.8 nm, respectively, which was established by TEM. It was found that Au, both in the NPs and the composite with methotrexate, was in the Au
Identifiants
pubmed: 37110074
pii: ma16083238
doi: 10.3390/ma16083238
pmc: PMC10146258
pii:
doi:
Types de publication
Journal Article
Langues
eng
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