Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies.

aging geroscience metabolic profiling metabolism metabolomics muscle wasting physical function protein sarcopenia systems biology

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
10 Apr 2023
Historique:
received: 03 03 2023
revised: 07 04 2023
accepted: 09 04 2023
medline: 28 4 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S,

Identifiants

pubmed: 37110200
pii: metabo13040542
doi: 10.3390/metabo13040542
pmc: PMC10147014
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : European Commission
ID : 278803
Organisme : Fondazione Roma
ID : NCDs Call for Proposals 2013
Organisme : Catholic University of the Sacred Heart
ID : D1.2020
Organisme : Catholic University of the Sacred Heart
ID : D1.2022
Organisme : Ministero della Salute
ID : Ricerca corrente 2023
Organisme : Centro Studi Achille e Linda Lorenzon
ID : N/A

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Riccardo Calvani (R)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Anna Picca (A)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.

Leocadio Rodriguez-Mañas (L)

Servicio de Geriatría, Hospital Universitario de Getafe, 28905 Getafe, Spain.
Centro de Investigación Biomédica en Red "Fragilidad y Envejecimiento Saludable" (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Matteo Tosato (M)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.

Hélio José Coelho-Júnior (HJ)

Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Alessandra Biancolillo (A)

Department of Physical and Chemical Sciences, Università degli Studi dell'Aquila, 67100 L'Aquila, Italy.

Olga Laosa (O)

Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.
Geriatric Research Group, Biomedical Research Foundation at Getafe University Hospital, 28905 Getafe, Spain.

Jacopo Gervasoni (J)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.

Aniello Primiano (A)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.

Lavinia Santucci (L)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.

Ottavia Giampaoli (O)

Department of Chemistry, Sapienza Università di Roma, 00185 Rome, Italy.

Isabelle Bourdel-Marchasson (I)

Clinical Gerontology Department, Bordeaux University Hospital, 33000 Bordeaux, France.
CRMSB, CNRS UMR 5536, Université de Bordeaux, 33000 Bordeaux, France.

Sophie C Regueme (SC)

CHU Bordeaux, Pole Gérontologie Clinique, 33000 Bordeaux, France.

Alan J Sinclair (AJ)

Foundation for Diabetes Research in Older People (fDROP), King's College, London WC2R 2LS, UK.

Andrea Urbani (A)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Francesco Landi (F)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Giovanni Gambassi (G)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Federico Marini (F)

Department of Chemistry, Sapienza Università di Roma, 00185 Rome, Italy.

Emanuele Marzetti (E)

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Classifications MeSH