Cervicovaginal Microbiota Profiles in Precancerous Lesions and Cervical Cancer among Ethiopian Women.
Ethiopia
Tikur Anbessa Specialized Hospital
cervical intraepithelial neoplasia
cervical microbiota
high-risk HPV
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
24 Mar 2023
24 Mar 2023
Historique:
received:
01
02
2023
revised:
15
03
2023
accepted:
17
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in the development of cervical cancer. The current study aimed to characterize the cervicovaginal microbiota in women with premalignant dysplasia or invasive cervical cancer compared with that of healthy women. The study comprised 120 Ethiopian women (60 cervical cancer patients who had not received any treatment, 25 patients with premalignant dysplasia, and 35 healthy women). Cervicovaginal specimens were collected using either an Isohelix DNA buccal swab or an Evalyn brush, and ribosomal RNA sequencing was used to characterize the cervicovaginal microbiota. Shannon and Simpson diversity indices were used to evaluate alpha diversity. Beta diversity was examined using principal coordinate analysis of weighted UniFrac distances. Alpha diversity was significantly higher in patients with cervical cancer than in patients with dysplasia and in healthy women (
Identifiants
pubmed: 37110255
pii: microorganisms11040833
doi: 10.3390/microorganisms11040833
pmc: PMC10144031
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Sister Institution Network Fund (SINF)
ID : 2019-20 (AK)
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