Molecular In-Depth on the Epidemiological Expansion of SARS-CoV-2 XBB.1.5.
COVID-18
SARS-CoV-2
XBB.1.5
molecular epidemiology
pandemics
phylogenomics
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
31 Mar 2023
31 Mar 2023
Historique:
received:
04
03
2023
revised:
25
03
2023
accepted:
27
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Since the beginning of the pandemic, the generation of new variants periodically recurs. The XBB.1.5 SARS-CoV-2 variant is one of the most recent. This research was aimed at verifying the potential hazard of this new subvariant. To achieve this objective, we performed a genome-based integrative approach, integrating results from genetic variability/phylodynamics with structural and immunoinformatic analyses to obtain as comprehensive a viewpoint as possible. The Bayesian Skyline Plot (BSP) shows that the viral population size reached the plateau phase on 24 November 2022, and the number of lineages peaked at the same time. The evolutionary rate is relatively low, amounting to 6.9 × 10
Identifiants
pubmed: 37110335
pii: microorganisms11040912
doi: 10.3390/microorganisms11040912
pmc: PMC10142263
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FONDAZIONE DI SARDEGNA bando 2022-2023 for the Dipartimento di Scienze Biomediche - UNISS (to Fabio Scarpa and Daria Sanna)
ID : NA
Organisme : PON "Ricerca e Innovazione" 2014-2020 (Marta Giovanetti)
ID : NA
Organisme : CRP-ICGEB RESEARCH GRANT 2020 Project CRP/BRA20-03 (Marta Giovanetti)
ID : contract CRP/20/03, Oswaldo Cruz Foundation
Organisme : Sapienza (Stefano Pascarella)
ID : RP12117A7670A1E8
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