Infection Induced Fetal Inflammatory Response Syndrome (FIRS): State-of- the-Art and Medico-Legal Implications-A Narrative Review.
causal link
fetal inflammatory response syndrome
medical liability
medico-legal compensation
placental pathology
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
12 Apr 2023
12 Apr 2023
Historique:
received:
24
02
2023
revised:
21
03
2023
accepted:
10
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Fetal inflammatory response syndrome (FIRS) represents the fetal inflammatory reaction to intrauterine infection or injury, potentially leading to multiorgan impairment, neonatal mortality, and morbidity. Infections induce FIRS after chorioamnionitis (CA), defined as acute maternal inflammatory response to amniotic fluid infection, acute funisitis and chorionic vasculitis. FIRS involves many molecules, i.e., cytokines and/or chemokines, able to directly or indirectly damage fetal organs. Therefore, due to FIRS being a condition with a complex etiopathogenesis and multiple organ dysfunction, especially brain injury, medical liability is frequently claimed. In medical malpractice, reconstruction of the pathological pathways is paramount. However, in cases of FIRS, ideal medical conduct is hard to delineate, due to uncertainty in diagnosis, treatment, and prognosis of this highly complex condition. This narrative review revises the current knowledge of FIRS caused by infections, maternal and neonatal diagnosis and treatments, the main consequences of the disease and their prognoses, and discusses the medico-legal implications.
Identifiants
pubmed: 37110434
pii: microorganisms11041010
doi: 10.3390/microorganisms11041010
pmc: PMC10142209
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Semin Fetal Neonatal Med. 2020 Aug;25(4):101111
pubmed: 32299712
Forensic Sci Int. 2021 Oct;327:110968
pubmed: 34455399
Surg Today. 2012 May;42(5):431-4
pubmed: 22068677
Semin Fetal Neonatal Med. 2020 Aug;25(4):101142
pubmed: 32912755
Semin Fetal Neonatal Med. 2020 Aug;25(4):101141
pubmed: 32739414
Pediatr Dev Pathol. 2003 Sep-Oct;6(5):435-48
pubmed: 14708737
Sci Rep. 2016 Dec 01;6:37932
pubmed: 27905410
J Matern Fetal Neonatal Med. 2011 Mar;24(3):391-6
pubmed: 20701435
Semin Fetal Neonatal Med. 2020 Aug;25(4):101137
pubmed: 33158496
Lancet Neurol. 2009 Jan;8(1):110-24
pubmed: 19081519
Nat Rev Neurol. 2015 Apr;11(4):192-208
pubmed: 25686754
Am J Obstet Gynecol. 2009 Nov;201(5):477.e1-7
pubmed: 19608153
Indian J Pediatr. 2012 Jan;79(1):48-51
pubmed: 21625842
Cell Tissue Res. 2005 Jun;320(3):369-78
pubmed: 15846513
Int J Environ Res Public Health. 2022 Jul 20;19(14):
pubmed: 35886672
Semin Fetal Neonatal Med. 2006 Jun;11(3):166-73
pubmed: 16564756
Semin Fetal Neonatal Med. 2020 Aug;25(4):101127
pubmed: 32571668
Am J Obstet Gynecol. 2008 Jan;198(1):43.e1-5
pubmed: 18166302
Am J Obstet Gynecol. 2004 Dec;191(6):2010-5
pubmed: 15592284
J Forensic Leg Med. 2011 Apr;18(3):97-100
pubmed: 21420644
Obstet Gynecol. 2017 Aug;130(2):e95-e101
pubmed: 28742677
Am J Clin Pathol. 2004 Nov;122(5):765-71
pubmed: 15491973
Rev Bras Ginecol Obstet. 2015 May;37(5):241-6
pubmed: 26107576
Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S29-52
pubmed: 26428501
J Matern Fetal Neonatal Med. 2019 Feb;32(3):488-492
pubmed: 28942689
Semin Fetal Neonatal Med. 2020 Aug;25(4):101146
pubmed: 33164775
NeuroRehabilitation. 2010;26(1):27-33
pubmed: 20130353
Pediatr Dev Pathol. 2016 Jan-Feb;19(1):24-30
pubmed: 26230300
Semin Fetal Neonatal Med. 2020 Aug;25(4):101112
pubmed: 32303464
J Child Neurol. 2005 Dec;20(12):940-9
pubmed: 16417840
Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):3-18
pubmed: 12732219
Forensic Sci Int. 1989 Jan;40(1):79-84
pubmed: 2925133
PLoS One. 2019 Nov 19;14(11):e0225328
pubmed: 31743377
Gynecol Obstet Fertil. 2010 Apr;38(4):261-77
pubmed: 20378389
Am J Obstet Gynecol. 2019 Apr;220(4):348-353
pubmed: 30529344
Pediatr Neonatol. 2018 Jun;59(3):231-237
pubmed: 29066072
Semin Fetal Neonatal Med. 2014 Oct;19(5):317-21
pubmed: 25150792
Clin Microbiol Infect. 2011 Sep;17(9):1304-11
pubmed: 21672080
J Neonatal Perinatal Med. 2018;11(2):109-114
pubmed: 29710738
Ceska Gynekol. 2021 Spring;86(2):80-85
pubmed: 34020553
Obstet Gynecol. 1996 Oct;88(4 Pt 1):534-9
pubmed: 8841213
Gynecol Obstet Fertil. 2011 Jun;39(6):383-7
pubmed: 21602077
Semin Fetal Neonatal Med. 2020 Aug;25(4):101140
pubmed: 33158495
J Matern Fetal Neonatal Med. 2011 Jan;24(1):37-42
pubmed: 20698737
Neurology. 2001 May 22;56(10):1278-84
pubmed: 11376173
Obstet Gynecol. 2020 Mar;135(3):e80-e97
pubmed: 32080050
Semin Fetal Neonatal Med. 2014 Oct;19(5):279-84
pubmed: 25150795
N Engl J Med. 2000 May 18;342(20):1500-7
pubmed: 10816189
Gynecol Obstet Fertil. 2011 Mar;39(3):146-73
pubmed: 21354846
Pediatr Neurol. 2016 Dec;65:78-85
pubmed: 27567289
S Afr Med J. 2021 Mar 31;111(3b):280-288
pubmed: 33944711
J Pediatr. 2013 Sep;163(3):652-7.e1-2
pubmed: 23664630
Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3813-3820
pubmed: 31525777
Am J Obstet Gynecol. 2015 Apr;212(4):482.e1-482.e12
pubmed: 25687566
Semin Fetal Neonatal Med. 2020 Aug;25(4):101110
pubmed: 32303463
J Matern Fetal Neonatal Med. 2021 Dec;34(23):3902-3914
pubmed: 31852288
Am J Perinatol. 2016 Dec;33(14):1337-1356
pubmed: 27159203
J Reprod Immunol. 1998 Feb;37(2):155-61
pubmed: 9571569
Obstet Gynecol. 1992 Jan;79(1):64-70
pubmed: 1727589
Obstet Gynecol. 2016 Mar;127(3):426-436
pubmed: 26855098
Semin Fetal Neonatal Med. 2020 Aug;25(4):101128
pubmed: 32928678
J Clin Pathol. 2013 Mar;66(3):243-8
pubmed: 23268318
Semin Fetal Neonatal Med. 2020 Aug;25(4):101143
pubmed: 32800654
Semin Fetal Neonatal Med. 2012 Feb;17(1):20-5
pubmed: 21865101
Hum Pathol. 2003 Jun;34(6):517-21; discussion 522-7
pubmed: 12827604
Cochrane Database Syst Rev. 2017 Jan 04;1:CD005302
pubmed: 28050900
Am J Obstet Gynecol. 2012 Dec;207(6):473.e1-7
pubmed: 22964068