α-Tocopherol Protects Lipopolysaccharide-Activated BV2 Microglia.
Humans
Lipopolysaccharides
/ pharmacology
Microglia
alpha-Tocopherol
/ pharmacology
Neuroprotective Agents
/ pharmacology
Phosphatidylinositol 3-Kinases
/ metabolism
Macrophages
/ metabolism
Anti-Inflammatory Agents
/ pharmacology
Vitamin E
/ pharmacology
Neurodegenerative Diseases
/ drug therapy
Nitric Oxide
/ metabolism
NF-kappa B
/ metabolism
antioxidant action
central nervous system
inflammation
microglia
neuroprotective effects
vitamin E
α-tocopherol
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Apr 2023
10 Apr 2023
Historique:
received:
16
03
2023
revised:
03
04
2023
accepted:
06
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Microglia, the resident macrophage-like population in the central nervous system, play a crucial role in the pathogenesis of many neurodegenerative disorders by triggering an inflammatory response that leads to neuronal death. Neuroprotective compounds to treat or prevent neurodegenerative diseases are a new field of study in modern medicine. Microglia are activated in response to inflammatory stimuli. The pathogenesis of various neurodegenerative diseases is closely related to the constant activation of microglia due to their fundamental role as a mediator of inflammation in the brain environment. α-Tocopherol, also known as vitamin E, is reported to possess potent neuroprotective effects. The goal of this study was to investigate the biological effects of vitamin E on BV2 microglial cells, as a possible neuroprotective and anti-inflammatory agent, following stimulation with lipopolysaccharide (LPS). The results showed that the pre-incubation of microglia with α-tocopherol can guarantee neuroprotective effects during microglial activation induced by LPS. α-Tocopherol preserved the branched morphology typical of microglia in a physiological state. It also reduced the migratory capacity; the production of pro-inflammatory and anti-inflammatory cytokines such as TNF-α and IL-10; and the activation of receptors such as TRL4 and CD40, which modulate the PI3K-Akt signaling pathway. The results of this study require further insights and research, but they present new scenarios for the application of vitamin E as an antioxidant for the purpose of greater neuroprotection in vivo for the prevention of possible neurodegenerative diseases.
Identifiants
pubmed: 37110573
pii: molecules28083340
doi: 10.3390/molecules28083340
pmc: PMC10141518
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
alpha-Tocopherol
H4N855PNZ1
Neuroprotective Agents
0
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Anti-Inflammatory Agents
0
Vitamin E
1406-18-4
Nitric Oxide
31C4KY9ESH
NF-kappa B
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Free Radic Biol Med. 2008 Apr 1;44(7):1452-64
pubmed: 18242194
Front Cell Neurosci. 2018 Dec 18;12:488
pubmed: 30618635
Physiol Rev. 2011 Apr;91(2):461-553
pubmed: 21527731
Nat Commun. 2014 May 21;5:3944
pubmed: 24845831
Arch Neurol. 2000 Sep;57(9):1265-70
pubmed: 10987892
Neurology. 2005 Feb 22;64(4):728-30
pubmed: 15728303
Front Neurol. 2019 Jun 12;10:585
pubmed: 31244753
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):210-21
pubmed: 12871028
Mol Aspects Med. 2018 Jun;61:92-103
pubmed: 28624327
J Immunol Res. 2017;2017:5150678
pubmed: 29410971
Crit Rev Food Sci Nutr. 2016;56(1):128-40
pubmed: 24915325
Front Cell Neurosci. 2018 Jul 24;12:215
pubmed: 30087595
Glia. 2010 Jul;58(9):1133-44
pubmed: 20468054
Brain Behav Immun. 2009 Mar;23(3):309-17
pubmed: 18814846
J Biol Chem. 2005 Jul 22;280(29):26649-52
pubmed: 15929991
J Pharmacol Exp Ther. 2017 Jan;360(1):201-205
pubmed: 27754930
Int J Mol Sci. 2016 Nov 25;17(12):
pubmed: 27897980
Neurobiol Dis. 2016 Dec;96:248-260
pubmed: 27659107
Nat Neurosci. 2007 Nov;10(11):1387-94
pubmed: 17965659
Int J Mol Sci. 2021 Mar 16;22(6):
pubmed: 33809762
Mol Vis. 2009;15:855-60
pubmed: 19390643
Biosensors (Basel). 2019 Dec 21;10(1):
pubmed: 31877825
Immunity. 2020 Feb 18;52(2):222-240
pubmed: 31924476
Cell. 2010 Mar 19;140(6):918-34
pubmed: 20303880
Immunol Today. 1996 Oct;17(10):487-92
pubmed: 8908815
Redox Biol. 2019 Sep;26:101259
pubmed: 31254734
J Neuroimmune Pharmacol. 2007 Dec;2(4):297-312
pubmed: 18040848
Brain Res. 1999 Oct 16;845(1):50-9
pubmed: 10529443
Immunology. 2010 Feb;129(2):154-69
pubmed: 20561356
Science. 1993 Oct 29;262(5134):689-95
pubmed: 7901908
Eur J Neurosci. 2001 Feb;13(3):529-38
pubmed: 11168560
Annu Rev Immunol. 2009;27:119-45
pubmed: 19302036
Front Aging Neurosci. 2017 May 26;9:148
pubmed: 28603493
Glia. 2011 Dec;59(12):1793-9
pubmed: 21901756
Biomolecules. 2020 Jul 09;10(7):
pubmed: 32659950
Cell Mol Life Sci. 2001 Jan;58(1):4-43
pubmed: 11229815
CNS Drugs. 2003;17(1):47-62
pubmed: 12467492
Mol Cell Biochem. 2006 Jul;287(1-2):21-32
pubmed: 16645729
Antioxidants (Basel). 2018 Apr 28;7(5):
pubmed: 29710809
Life Sci. 2006 Mar 27;78(18):2088-98
pubmed: 16458936
Mediators Inflamm. 2016;2016:5240127
pubmed: 27738387
Sultan Qaboos Univ Med J. 2014 May;14(2):e157-65
pubmed: 24790736
Sci STKE. 2004 Jun 09;2004(237):pe25
pubmed: 15199223
Neurochem Res. 2021 Jul;46(7):1725-1736
pubmed: 33821438
Brain Sci. 2021 Aug 20;11(8):
pubmed: 34439717
Annu Rev Immunol. 2002;20:197-216
pubmed: 11861602
Front Immunol. 2018 Nov 15;9:2650
pubmed: 30524429
J Neurosci Res. 2001 Oct 15;66(2):163-70
pubmed: 11592111
Biochim Biophys Acta. 2000 Jul 26;1502(1):139-44
pubmed: 10899439
J Immunol. 2006 Feb 1;176(3):1402-10
pubmed: 16424167
Mol Med Rep. 2018 Apr;17(4):5484-5491
pubmed: 29393460
Cell Immunol. 2020 Nov;357:104200
pubmed: 32979761
Int J Mol Sci. 2019 Aug 09;20(16):
pubmed: 31405021
Physiol Rev. 2014 Jul;94(3):909-50
pubmed: 24987008
Int Immunopharmacol. 2016 Jul;36:282-290
pubmed: 27208432
Annu Rev Immunol. 2014;32:367-402
pubmed: 24471431
J Neuroinflammation. 2014 Jun 03;11:98
pubmed: 24889886
Curr Opin Neurobiol. 2017 Dec;47:146-155
pubmed: 29096243
Neurobiol Aging. 2004 Mar;25(3):311-4
pubmed: 15123336
Biology (Basel). 2022 Sep 29;11(10):
pubmed: 36290330
Cell. 2006 Feb 24;124(4):783-801
pubmed: 16497588
Front Immunol. 2019 May 09;10:1043
pubmed: 31143184
Int Immunopharmacol. 2015 Feb;24(2):369-376
pubmed: 25576658
Biomolecules. 2020 Jan 14;10(1):
pubmed: 31947676
BMC Neurosci. 2006 Apr 03;7:29
pubmed: 16584562
J Neurosci. 2000 Feb 1;20(3):1036-43
pubmed: 10648709
Transl Neurodegener. 2012 Apr 24;1(1):9
pubmed: 23210447
Transl Neurodegener. 2020 Nov 26;9(1):42
pubmed: 33239064
Nutr Metab (Lond). 2005 Oct 17;2:28
pubmed: 16229744
Prog Neurobiol. 2019 Jul;178:101612
pubmed: 30954517
Brain Res Rev. 2009 Mar;59(2):278-92
pubmed: 18822314
J Dairy Sci. 2018 Aug;101(8):6866-6871
pubmed: 29885892
Environ Health Prev Med. 2001 Jan;5(4):138-43
pubmed: 21432402
J Am Diet Assoc. 1979 Dec;75(6):647-65
pubmed: 389993
Dev Neurobiol. 2009 Jan;69(1):60-72
pubmed: 19025930
Pediatr Res. 1976 May;10(5):536-40
pubmed: 934725
J Neuroimmunol. 2004 Apr;149(1-2):101-9
pubmed: 15020070
Exp Gerontol. 2010 Nov;45(11):882-95
pubmed: 20705127
Free Radic Biol Med. 2011 Sep 1;51(5):1000-13
pubmed: 21664268
Prog Lipid Res. 2000 May;39(3):231-55
pubmed: 10799717
Science. 1922 Dec 8;56(1458):650-1
pubmed: 17838496