The Mechanical Properties of Blended Fibrinogen:Polycaprolactone (PCL) Nanofibers.
diameter dependence
electrospinning
fibrinogen
mechanical properties
nanofibers
polycaprolactone
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
13 Apr 2023
13 Apr 2023
Historique:
received:
31
03
2023
revised:
10
04
2023
accepted:
11
04
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Electrospinning is a process to produce versatile nanoscale fibers. In this process, synthetic and natural polymers can be combined to produce novel, blended materials with a range of physical, chemical, and biological properties. We electrospun biocompatible, blended fibrinogen:polycaprolactone (PCL) nanofibers with diameters ranging from 40 nm to 600 nm, at 25:75 and 75:25 blend ratios and determined their mechanical properties using a combined atomic force/optical microscopy technique. Fiber extensibility (breaking strain), elastic limit, and stress relaxation times depended on blend ratios but not fiber diameter. As the fibrinogen:PCL ratio increased from 25:75 to 75:25, extensibility decreased from 120% to 63% and elastic limit decreased from a range between 18% and 40% to a range between 12% and 27%. Stiffness-related properties, including the Young's modulus, rupture stress, and the total and relaxed, elastic moduli (Kelvin model), strongly depended on fiber diameter. For diameters less than 150 nm, these stiffness-related quantities varied approximately as
Identifiants
pubmed: 37110944
pii: nano13081359
doi: 10.3390/nano13081359
pmc: PMC10145448
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Center for Functional Materials, Wake Forest University
ID : CG0017 590010 U04323
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