Associations of VEGF-A-Related Variants with Adolescent Cardiometabolic and Dietary Parameters.
adolescents
cardiometabolic profile
dietary patterns
genetic risk score
vascular endothelial growth factor A (VEGF-A)
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 Apr 2023
13 Apr 2023
Historique:
received:
13
03
2023
revised:
07
04
2023
accepted:
12
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Previous research has allowed the identification of variants related to the vascular endothelial growth factor-A (VEGF-A) and their association with anthropometric, lipidemic and glycemic indices. The present study examined potential relations between key VEGF-A-related single-nucleotide polymorphisms (SNPs), cardiometabolic parameters and dietary habits in an adolescent cohort. Cross-sectional analyses were conducted using baseline data from 766 participants of the Greek TEENAGE study. Eleven VEGF-A-related SNPs were examined for associations with cardiometabolic indices through multivariate linear regressions after adjusting for confounding factors. A 9-SNP unweighted genetic risk score (uGRS) for increased VEGF-A levels was constructed to examine associations and the effect of its interactions with previously extracted dietary patterns for the cohort. Two variants (rs4416670, rs7043199) displayed significant associations (
Identifiants
pubmed: 37111103
pii: nu15081884
doi: 10.3390/nu15081884
pmc: PMC10143198
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Social Fund-ESF of the European Union
Organisme : National Strategic Reference Framework (NSRF)
ID : Research Funding Program: Heracleitus II through its Operational Program "Education and Lifelong Learning"
Organisme : La Région Grand Est, France-GUTENBERG chair 2018
ID : 18CP-1413
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