Binding Parameters of [
PET imaging
metabolism
microtubules
radiochemistry
stability
translational molecular imaging
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
27 Mar 2023
27 Mar 2023
Historique:
received:
24
02
2023
revised:
18
03
2023
accepted:
21
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer's disease (AD), Parkinson's disease and other neurological disorders. Increasing scientific evidence indicates that MT-stabilizing agents protect against the deleterious effects of neurodegeneration in treating AD. To quantify these protective benefits, we developed the first brain-penetrant PET radiopharmaceutical, [
Identifiants
pubmed: 37111252
pii: ph16040495
doi: 10.3390/ph16040495
pmc: PMC10140836
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : R01 AG065839
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG065839
Pays : United States
Références
J Nucl Med. 1979 Apr;20(4):350-7
pubmed: 43884
J Med Chem. 2018 Mar 8;61(5):2118-2123
pubmed: 29457976
Curr Alzheimer Res. 2005 Jul;2(3):335-41
pubmed: 15974899
Front Med (Lausanne). 2022 Feb 28;9:817274
pubmed: 35295607
J Alzheimers Dis. 2013;33 Suppl 1:S123-39
pubmed: 22710920
J Neurooncol. 2014 Jun;118(2):335-343
pubmed: 24740196
Radiology. 1975 Jan;114(1):89-98
pubmed: 1208874
Br J Pharmacol. 2010 Nov;161(6):1219-37
pubmed: 20132208
Cancer Res. 2007 Jun 15;67(12):5865-71
pubmed: 17575155
J Med Chem. 2016 Oct 13;59(19):8685-8711
pubmed: 27348355
Cell Motil Cytoskeleton. 2009 Aug;66(8):635-49
pubmed: 19479823
Appl Radiat Isot. 2001 Feb;54(2):203-8
pubmed: 11200881
Front Cell Neurosci. 2015 Sep 09;9:343
pubmed: 26441521
J Neurochem. 2008 Mar;104(6):1433-9
pubmed: 18088381
Mol Imaging Biol. 2003 Nov-Dec;5(6):376-89
pubmed: 14667492
J Alzheimers Dis. 2017;57(4):975-999
pubmed: 27567878
J Neurooncol. 2012 Nov;110(2):257-64
pubmed: 22932984
Lancet Neurol. 2020 Nov;19(11):951-962
pubmed: 33098804
Annu Rev Biophys. 2014;43:141-69
pubmed: 24702007
Neurosci Bull. 2014 Apr;30(2):346-58
pubmed: 24733656
Molecules. 2020 May 13;25(10):
pubmed: 32414052
Acta Neuropathol. 2009 Jul;118(1):53-69
pubmed: 19184068
J Cell Sci. 2013 Jun 1;126(Pt 11):2319-29
pubmed: 23729742
J Nucl Med. 1975 Mar;16(3):210-24
pubmed: 1113170
J Cell Biol. 1991 Nov;115(3):717-30
pubmed: 1918161
J Genet Syndr Gene Ther. 2013 Dec 6;4:203
pubmed: 24563812
Mol Biol Rep. 2021 Apr;48(4):3871-3876
pubmed: 33880672
JAMA Neurol. 2014 Apr;71(4):505-8
pubmed: 24493463
CNS Neurosci Ther. 2011 Oct;17(5):514-24
pubmed: 20553310
Mol Imaging Biol. 2014 Dec;16(6):773-80
pubmed: 24865402
Front Aging Neurosci. 2022 Apr 22;14:838034
pubmed: 35527737
Curr Opin Cell Biol. 2001 Feb;13(1):41-8
pubmed: 11163132
EJNMMI Res. 2022 Jul 26;12(1):41
pubmed: 35881263
Trends Cell Biol. 2013 Dec;23(12):634-43
pubmed: 24091156
Biochim Biophys Acta. 2005 Jan 3;1739(2-3):240-50
pubmed: 15615642
Mol Neurodegener. 2019 Aug 2;14(1):32
pubmed: 31375134
Neurobiol Dis. 2017 Sep;105:328-335
pubmed: 28012891