Plant-Produced Anti-Zika Virus Monoclonal Antibody Glycovariant Exhibits Abrogated Antibody-Dependent Enhancement of Infection.
Fc effector function
Zika virus
antibody dependent enhancement of infection (ADE)
antibody-dependent cellular cytotoxicity (ADCC)
glycosylation
monoclonal antibody (mAb)
neutralization
plant-made antibody
plant-made pharmaceutical
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
29 Mar 2023
29 Mar 2023
Historique:
received:
03
03
2023
revised:
27
03
2023
accepted:
28
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Monoclonal antibodies (mAb) against the envelope (E) protein of Zika virus (ZIKV) have shown great potential as therapeutics against the Zika epidemics. However, their use as a therapy may predispose treated individuals to severe infection by the related dengue virus (DENV) via antibody-dependent enhancement of infection (ADE). Here, we generated a broadly neutralizing flavivirus mAb, ZV1, with an identical protein backbone but different Fc glycosylation profiles. The three glycovariants, produced in wild-type (WT) and glycoengineered ΔXF
Identifiants
pubmed: 37112665
pii: vaccines11040755
doi: 10.3390/vaccines11040755
pmc: PMC10144123
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103476
Pays : United States
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