Immunogenicity and In Vivo Protective Effects of Recombinant Nucleocapsid-Based SARS-CoV-2 Vaccine Convacell

COVID-19 SARS-CoV-2 nucleocapsid protein N vaccine

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
20 Apr 2023
Historique:
received: 02 04 2023
revised: 14 04 2023
accepted: 18 04 2023
medline: 28 4 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

The vast majority of SARS-CoV-2 vaccines which are licensed or under development focus on the spike (S) protein and its receptor binding domain (RBD). However, the S protein shows considerable sequence variations among variants of concern. The aim of this study was to develop and characterize a SARS-CoV-2 vaccine targeting the highly conserved nucleocapsid (N) protein. Recombinant N protein was expressed in

Identifiants

pubmed: 37112786
pii: vaccines11040874
doi: 10.3390/vaccines11040874
pmc: PMC10141225
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Sevastyan O Rabdano (SO)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Ellina A Ruzanova (EA)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Iuliia V Pletyukhina (IV)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Nikita S Saveliev (NS)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Kirill L Kryshen (KL)

RMC "Home of Pharmacy" JSC, Kuzmolovsky 188663, Russia.

Anastasiia E Katelnikova (AE)

RMC "Home of Pharmacy" JSC, Kuzmolovsky 188663, Russia.

Petr P Beltyukov (PP)

Scientific Research Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical-Biological Agency of Russia (SRIHOPHE), Kuzmolovsky 188663, Russia.

Liliya N Fakhretdinova (LN)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Ariana S Safi (AS)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

German O Rudakov (GO)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Sergei A Arakelov (SA)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Igor V Andreev (IV)

National Research Center Institute of Immunology (NRCII), Federal Medical-Biological Agency of Russia, Moscow 115522, Russia.

Ilya A Kofiadi (IA)

National Research Center Institute of Immunology (NRCII), Federal Medical-Biological Agency of Russia, Moscow 115522, Russia.
Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow 117997, Russia.

Musa R Khaitov (MR)

National Research Center Institute of Immunology (NRCII), Federal Medical-Biological Agency of Russia, Moscow 115522, Russia.
Department of Immunology, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow 117997, Russia.

Rudolf Valenta (R)

National Research Center Institute of Immunology (NRCII), Federal Medical-Biological Agency of Russia, Moscow 115522, Russia.
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow 119435, Russia.
Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.

Daria S Kryuchko (DS)

Federal Medical-Biological Agency of Russia, Moscow 125310, Russia.

Igor A Berzin (IA)

Federal Medical-Biological Agency of Russia, Moscow 125310, Russia.

Natalia S Belozerova (NS)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Anatoly E Evtushenko (AE)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Viktor P Truhin (VP)

Saint Petersburg Scientific Research Institute of Vaccines and Serums of the Federal Medical-Biological Agency of Russia (SPbSRIVS), St. Petersburg 198320, Russia.

Veronika I Skvortsova (VI)

Federal Medical-Biological Agency of Russia, Moscow 125310, Russia.

Classifications MeSH