Longitudinal Detection of Twenty DNA and RNA Viruses in Allogeneic Hematopoietic Stem Cell Transplant Recipients Plasma.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
07 04 2023
Historique:
received: 12 02 2023
revised: 29 03 2023
accepted: 05 04 2023
medline: 1 5 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

Metagenomics revealed novel and routinely overlooked viruses, representing sources of unrecognized infections after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We aim to describe DNA and RNA virus prevalence and kinetics in allo-HSCT recipients' plasma for one year post HSCT. We included 109 adult patients with first allo-HSCT from 1 March 2017 to 31 January 2019 in this observational cohort study. Seventeen DNA and three RNA viral species were screened with qualitative and/or quantitative r(RT)-PCR assays using plasma samples collected at 0, 1, 3, 6, and 12 months post HSCT. TTV infected 97% of patients, followed by HPgV-1 (prevalence: 26-36%). TTV (median 3.29 × 10

Identifiants

pubmed: 37112908
pii: v15040928
doi: 10.3390/v15040928
pmc: PMC10142697
pii:
doi:

Substances chimiques

DNA, Viral 0

Types de publication

Observational Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Marie-Céline Zanella (MC)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.

Diem-Lan Vu (DL)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.

Krisztina Hosszu-Fellous (K)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Geneva Centre for Emerging Viral Diseases, 1211 Geneva, Switzerland.

Dionysios Neofytos (D)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.

Chistian Van Delden (C)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.

Lara Turin (L)

Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.

Antoine Poncet (A)

Center for Clinical Research, Department of Health and Community Medicine, University of Geneva, 1206 Geneva, Switzerland.
Division of Clinical Epidemiology, Department of Health and Community Medicine, University Hospital of Geneva, 1211 Geneva, Switzerland.

Federico Simonetta (F)

Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.
Division of Hematology, Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland.

Stavroula Masouridi-Levrat (S)

Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.
Division of Hematology, Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland.

Yves Chalandon (Y)

Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.
Division of Hematology, Department of Oncology, Geneva University Hospitals, 1211 Geneva, Switzerland.

Samuel Cordey (S)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.

Laurent Kaiser (L)

Division of Infectious Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.
Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.
Faculty of Medicine, University of Geneva Medical School, 1206 Geneva, Switzerland.
Geneva Centre for Emerging Viral Diseases, 1211 Geneva, Switzerland.

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