Steady electrocorticogram characteristics predict specific stress-induced behavioral phenotypes.
EEG
fear
multisensorial stress
theta
vulnerability
β2
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2023
2023
Historique:
received:
18
09
2022
accepted:
06
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Depending on the individual, exposure to an intense stressor may, or may not, lead to a stress-induced pathology. Predicting the physiopathological evolution in an individual is therefore an important challenge, at least for prevention. In this context, we developed an ethological model of simulated predator exposure in rats: we call this the multisensorial stress model (MSS). We hypothesized that: (i) MSS exposure can induce stress-induced phenotypes, and (ii) an electrocorticogram (ECoG) recorded before stress exposure can predict phenotypes observed after stress. Forty-five Sprague Dawley rats were equipped with ECoG telemetry and divided into two groups. The Stress group ( Three behaviors were observed in the Stress group: 39% developed a fear memory phenotype (freezing, avoidance, and hyperreactivity); 26% developed avoidance and anhedonia; and 35% made a full recovery. We also identified pre-stress ECoG biomarkers that accurately predicted cluster membership. Decreased chronic 24 h frontal Low θ relative power was associated with resilience; increased frontal Low θ relative power was associated with fear memory; and decreased parietal β2 frequency was associated with the avoidant-anhedonic phenotype. These predictive biomarkers open the way to preventive medicine for stress-induced diseases.
Identifiants
pubmed: 37113159
doi: 10.3389/fnins.2023.1047848
pmc: PMC10126346
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1047848Informations de copyright
Copyright © 2023 Desnouveaux, Poly, Edmond, Aphezberro, Coulon, Boutet, Le Coz, Fargeau, Linard, Caillol, Duffaud, Servonnet, Ferhani, Trousselard, Taudon, Canini and Claverie.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 Suppl:S3-14
pubmed: 2694228
Psychol Med. 2017 Oct;47(13):2260-2274
pubmed: 28385165
Genes Brain Behav. 2020 Nov;19(8):e12684
pubmed: 32666635
J Trauma Stress. 2007 Aug;20(4):413-22
pubmed: 17721971
Behav Brain Res. 2016 Jul 15;308:196-204
pubmed: 27102341
Front Psychiatry. 2019 Sep 20;10:657
pubmed: 31616324
Mol Psychiatry. 2016 May;21(5):630-41
pubmed: 26552592
Transl Psychiatry. 2017 Jan 10;7(1):e1000
pubmed: 28072410
J Clin Psychiatry. 1985 Sep;46(9):383-4
pubmed: 4030702
Cell. 2015 Jul 16;162(2):363-374
pubmed: 26186190
Eur Neuropsychopharmacol. 2015 Aug;25(8):1190-200
pubmed: 25936227
Front Psychiatry. 2022 Aug 03;13:827536
pubmed: 35990051
Neuroscience. 2013 Dec 19;254:98-109
pubmed: 24056197
Sci Rep. 2018 Jul 23;8(1):11041
pubmed: 30038341
Brain Struct Funct. 2020 Sep;225(7):2029-2044
pubmed: 32642914
Nat Rev Neurosci. 2010 Jul;11(7):503-13
pubmed: 20559337
Front Neurosci. 2015 Aug 25;9:292
pubmed: 26379483
Neurosci Biobehav Rev. 2007;31(3):441-64
pubmed: 17198729
J Vis Exp. 2011 Sep 01;(55):e3446
pubmed: 21912367
Soc Psychiatry Psychiatr Epidemiol. 2019 May;54(5):639-647
pubmed: 30003310
Front Neuroendocrinol. 2020 Apr;57:100820
pubmed: 31987814
World Psychiatry. 2016 Jun;15(2):185-6
pubmed: 27265715
Neurobiol Stress. 2018 Sep 21;9:176-187
pubmed: 30450383
Neuron. 2013 Nov 20;80(4):1039-53
pubmed: 24267654
Transl Psychiatry. 2018 Oct 5;8(1):209
pubmed: 30291225
Int J Neuropsychopharmacol. 2018 Nov 1;21(11):1049-1065
pubmed: 30239762
Neurobiol Stress. 2019 Jun 04;11:100180
pubmed: 31236437
Neuroscience. 2008 Feb 19;151(4):937-47
pubmed: 18201833
Physiol Behav. 2018 Feb 1;184:205-210
pubmed: 29223710
BMC Biol. 2021 Jun 3;19(1):116
pubmed: 34082731
J Am Coll Radiol. 2020 Jul;17(7):921-926
pubmed: 32479798
J Med Life. 2022 Apr;15(4):436-442
pubmed: 35646173
Front Behav Neurosci. 2022 Apr 04;16:852235
pubmed: 35444521
Nat Commun. 2019 May 30;10(1):2372
pubmed: 31147546
Behav Brain Res. 2019 May 2;363:1-12
pubmed: 30677449
J Affect Disord. 2021 Jun 1;288:175-188
pubmed: 33901698
Brain Res. 2004 Oct 29;1025(1-2):139-51
pubmed: 15464754
Behav Brain Res. 2023 Jan 5;436:114090
pubmed: 36057378
Neurosci Biobehav Rev. 2020 Jun;113:62-76
pubmed: 32169412
Sci Rep. 2017 Oct 20;7(1):13635
pubmed: 29057956
Behav Processes. 2019 Sep;166:103890
pubmed: 31254627
Am J Med Genet B Neuropsychiatr Genet. 2020 Mar;183(2):77-94
pubmed: 31583809
J Consult Clin Psychol. 2003 Aug;71(4):692-700
pubmed: 12924674
Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R459-71
pubmed: 23364525
J Interpers Violence. 2021 Mar;36(5-6):NP3153-NP3168
pubmed: 29683081
Neurosci Biobehav Rev. 2008 Sep;32(7):1259-66
pubmed: 18579206
Behav Brain Res. 2010 Dec 25;214(2):317-22
pubmed: 20595033
Behav Res Methods Instrum Comput. 2001 Aug;33(3):398-414
pubmed: 11591072
Transl Psychiatry. 2020 May 6;10(1):132
pubmed: 32376819
J Exp Psychol Anim Behav Process. 1978 Apr;4(2):95-103
pubmed: 670892
Neuropharmacology. 2011 Feb-Mar;60(2-3):381-7
pubmed: 20955718
Physiol Behav. 2017 Feb 1;169:189-194
pubmed: 27876638
Behav Biol. 1973 Jan;8(1):75-82
pubmed: 4734965
Front Neurosci. 2016 Nov 02;10:495
pubmed: 27853418
Biol Psychiatry. 2021 May 1;89(9):920-928
pubmed: 33309017
Eur J Pharmacol. 2003 Feb 28;463(1-3):3-33
pubmed: 12600700
Rev Neurosci. 2020 Oct 25;31(7):703-722
pubmed: 32866132
J Neurosci. 2008 Nov 12;28(46):11825-9
pubmed: 19005047
Biol Psychiatry. 2002 Nov 15;52(10):958-75
pubmed: 12437937
Neurosci Biobehav Rev. 1990 Winter;14(4):463-72
pubmed: 2287483
PLoS One. 2015 Apr 24;10(4):e0123541
pubmed: 25909654
Nat Rev Dis Primers. 2015 Oct 08;1:15057
pubmed: 27189040
Neurosci Biobehav Rev. 2005;29(8):1265-77
pubmed: 16111751
Front Syst Neurosci. 2022 Mar 03;16:826475
pubmed: 35308564
Trauma Violence Abuse. 2022 Dec 2;:15248380221137686
pubmed: 36458866