Prediction models for neutralization activity against emerging SARS-CoV-2 variants: A cross-sectional study.

Despite extensive vaccination campaigns to combat the coronavirus disease (COVID-19) pandemic, variants of concern, particularly the Omicron variant (B.1.1.529 or BA.1), may escape the antibodies elicited by vaccination against SARS-CoV-2. Therefore, this study aimed to evaluate 50% neutralizing activity (NT We used a random 10% of samples from 1,277 participants in a population-based cross-sectional survey conducted in January and February 2022 in Yokohama City, the most populous municipality in Japan. We measured NT Among 123 participants aged 20-74, 93% had received two doses of SARS-CoV-2 vaccine. The geometric means (95% confidence intervals) of NT In a general Japanese population with 93% of the population vaccinated with two doses of SARS-CoV-2 vaccine, neutralizing activity against Omicron BA.1 and BA.2 were substantially lower than those against D614G or the Delta variant. The prediction models for Omicron BA.1 and BA.2 showed moderate predictive ability and the model for BA.1 performed well in validation data.

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Copyright © 2023 Goto, Miyakawa, Nakayama, Yagome, Xu, Kaneko, Ohtake, Kato and Ryo.

Déclaration de conflit d'intérêts

SY was employed by Integrity Healthcare Co., Ltd. NO was employed by Tosoh Corporation. HK received grants from Shionogi & Company, Limited, and Asahi Kasei Pharma Co., Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.