Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation.

Biofilms Biosafety Dynamic covalent bonds On-demand drug release Resistance reversal

Journal

Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 24 10 2022
revised: 29 03 2023
accepted: 14 04 2023
medline: 28 4 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

New antimicrobial strategies are urgently needed to meet the challenges posed by the emergence of drug-resistant bacteria and bacterial biofilms. This work reports the facile synthesis of antimicrobial dynamic covalent nano-networks (aDCNs) composing antibiotics bearing multiple primary amines, polyphenols, and a cross-linker acylphenylboronic acid. Mechanistically, the iminoboronate bond drives the formation of aDCNs, facilitates their stability, and renders them highly responsive to stimuli, such as low pH and high H

Identifiants

DOI: 10.1016/j.bioactmat.2023.04.014 PMID: 37113688 PMC: PMC10126917
pubmed: 37113688
doi: 10.1016/j.bioactmat.2023.04.014
pii: S2452-199X(23)00132-9
pmc: PMC10126917
doi:

Types de publication

Journal Article

Langues

eng

Pagination

288-302

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

Y.L., Y.F.Li, and H.C. declare the following competing interests: a patent has been filed covering the materials and methods reported herein. All other authors declare no other competing interests.

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Auteurs

Yuanfeng Li (Y)

Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Yin-Zi Piao (YZ)

Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, 325001, China.

Hua Chen (H)

Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, 325001, China.
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Keqing Shi (K)

Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Juqin Dai (J)

Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Siran Wang (S)

Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, 325001, China.

Tieli Zhou (T)

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Anh-Tuan Le (AT)

Nano Institute, Phenikaa University, Yen Nghia, Ha Dong, Ha Noi, Viet Nam.

Yaran Wang (Y)

Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, 325001, China.

Fan Wu (F)

Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Rujiang Ma (R)

Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Linqi Shi (L)

Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.

Yong Liu (Y)

Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, 325001, China.

Classifications MeSH