Is red distribution width a valid tool to predict impaired iron transport in heart failure?
heart failure
iron deficiency
iron metablism disorder
iron metabolism
red cell distribution width (RDW)
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
12
2022
accepted:
08
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis irrespective of anaemia. In this retrospective study we searched for a surrogate biomarker of IIT. We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients. At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison between the true and false negative groups showed that estimated glomerular filtration rate (eGFR) was significantly higher ( RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m
Sections du résumé
Background
UNASSIGNED
Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) where it negatively affects prognosis irrespective of anaemia.
Objectives
UNASSIGNED
In this retrospective study we searched for a surrogate biomarker of IIT.
Methods
UNASSIGNED
We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients.
Results
UNASSIGNED
At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison between the true and false negative groups showed that estimated glomerular filtration rate (eGFR) was significantly higher (
Conclusion
UNASSIGNED
RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m
Identifiants
pubmed: 37113703
doi: 10.3389/fcvm.2023.1133233
pmc: PMC10126241
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1133233Informations de copyright
© 2023 Campodonico, Carulli, Doni, Russo, Junod, Gaudenzi Asinelli, Bonomi, De Martino, Vignati, Pezzuto and Agostoni.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor MM declared a shared affiliation with the authors JC, AB, FDM, CV, BP, PA at the time of review.
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