Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination.

BCG scar BCG vaccine Vaccination technique Vaccine safety

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 18 10 2022
revised: 29 03 2023
accepted: 30 03 2023
medline: 28 4 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: epublish

Résumé

The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial ('BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers'; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination . Amongst 3071 BCG-recipients, 2341 (76%) developed a BCG scar. Scar prevalence was lowest in Spain and highest in UK. Absence of post-injection wheal (OR 0.4, 95%CI 0.2-0.9), BCG revaccination (OR 1.7, 95%CI 1.3-2.0), female sex (OR 2.0, 95%CI 1.7-2.4), older age (OR 0.4, 95%CI 0.4-0.5) and study country (Brazil OR 1.6, 95%CI 1.3-2.0) influenced BCG scar prevalence. Of the 2341 participants with a BCG scar, 1806 (77%) did not mind having the scar. Participants more likely to not mind were those in Brazil, males and those with a prior BCG vaccination history. The majority (96%) did not regret having the vaccine. Both vaccination-related (amenable to optimisation) and individual-related factors affected BCG scar prevalence 12 months following BCG vaccination of adults, with implications for maximising the effectiveness of BCG vaccination.

Identifiants

DOI: 10.1016/j.heliyon.2023.e15241 PMID: 37113782 PMC: PMC10126857
pubmed: 37113782
doi: 10.1016/j.heliyon.2023.e15241
pii: S2405-8440(23)02448-9
pmc: PMC10126857
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e15241

Subventions

Organisme : Bill & Melinda Gates Foundation
ID : INV-017302
Pays : United States
Organisme : Medical Research Council
ID : MR/V033417/1
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023 The Authors.

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Auteurs

Paola Villanueva (P)

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.

Nigel W Crawford (NW)

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
Immunisation Service, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.

Mariana Garcia Croda (MG)

School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.

Simone Collopy (S)

Department of Pediatrics, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.

Bruno Araújo Jardim (BA)

Carlos Borborema Clinical Research Institute, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.

Tyane de Almeida Pinto Jardim (T)

Carlos Borborema Clinical Research Institute, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.

Laurens Manning (L)

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
School of Medicine, University of Western Australia, Perth, WA, Australia.
Department of Infectious Diseases, Fiona Stanley Hospital, Perth, WA, Australia.

Michaela Lucas (M)

School of Medicine, University of Western Australia, Perth, WA, Australia.
Department of Immunology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Departments of Immunology, Perth Children's Hospital, Perth, WA, Australia.
Department of Immunology, Pathwest, QE2 Medical Centre, Perth, WA, Australia.

Helen Marshall (H)

Robinson Research Institute and Adelaide Medical School, The University of Adelaide and Department of Paediatrics, The Women's and Children's Health Network, Australia.

Cristina Prat-Aymerich (C)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Institut d'Investigació Germans Trias i Pujol, Departament de Genètica i Microbiologia, CIBER de enfermedades respiratorias (CIBERES), Instituto de Salud Carlos III, Universitat Autònoma de Barcelona, Catalunya, Badalona, Spain.

Alice Sawka (A)

Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia.

Ketaki Sharma (K)

National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia.
The Children's Hospital at Westmead, Westmead, NSW, Australia.

Darren Troeman (D)

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Ushma Wadia (U)

Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.

Adilia Warris (A)

Medical Research Council Centre for Medical Mycology, University of Exeter, UK.
Great Ormond Street Hospital, London, UK.

Nicholas Wood (N)

National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia.
The Children's Hospital at Westmead, Westmead, NSW, Australia.
The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia.

Nicole L Messina (NL)

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.

Nigel Curtis (N)

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.

Laure F Pittet (LF)

Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia.
Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia.
Infectious Diseases Unit, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva and University Hospitals of Geneva, Geneva, Switzerland.

Classifications MeSH