Prognostic Properties of the GOLD 2023 Classification System.

Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published an update on the Global Strategy for Prevention, Diagnosis and Management of COPD, introducing a new classification of chronic obstructive pulmonary disease (COPD). Our aim was to assess the prognostic value of the new GOLD classification system in comparison with the previous GOLD classification systems (GOLD stages I-IV and GOLD groups A-D) and the BODE index. We used the data of 784 patients with COPD from the Czech Multicenter Research Database of COPD. Patient survival was analyzed with the use of Kaplan-Meier estimate and Cox model of proportional risks. ROC analysis and area under curve (AUC) were used for comparison of GOLD classifications and BODE index. The analyses were performed with the use of software R (version 4.2.0). We analyzed data of 782 patients with complete data on GOLD classifications. The study population comprised 72.9% of men, 89.1% current or former smokers, with a mean age of 66.6 years, a mean BMI of 27.4 and a mean FEV We concluded that the new GOLD classification system has poor prognostic properties and that specific prediction tools (eg, the BODE index) should be used for mortality risk assessment.

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© 2023 Brat et al.

Déclaration de conflit d'intérêts

Dr Jaromir Zatloukal reports personal fees from AstraZeneca, personal fees from Boehringer-Ingelheim, personal fees from Chiesi, outside the submitted work. Dr Vladimir Koblizek reports grants, personal fees from Boehringer Ingelheim CZ, grants from Boehringer Ingelheim RCV, personal fees from AstraZeneca CZ, grants, personal fees from Angelini CZ, personal fees from Chiesi CZ, personal fees from Berlin Chemie CZ, during the conduct of the study; personal fees from MSD CZ, personal fees from Gilead CZ, outside the submitted work. The authors of this article report no other conflicts of interest with relevance to this study.