Burden of
Associated factors
Extra pulmonary tuberculosis
GeneXpert
Mycobacterial culture
Journal
IJID regions
ISSN: 2772-7076
Titre abrégé: IJID Reg
Pays: England
ID NLM: 9918418183106676
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
09
11
2022
revised:
02
03
2023
accepted:
11
03
2023
medline:
28
4
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Extra pulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis (TB), a devastating disease of public health concern. The complexity of the cases, the involvement of many organs, resource constraints, and concerns regarding drug resistance make disease diagnosis and treatment difficult. This study aimed to determine the burden of tuberculosis and associated factors among presumptive EPTB patients in selected hospitals in Addis Ababa. A cross-sectional study was conducted from February to August 2022 in selected public hospitals in Addis Ababa. Those who attended the hospitals and were presumptively diagnosed as EPTB patient were included in the study. Sociodemographic and clinical data were collected using a semistructured questionnaire. The GeneXpert MTB/RIF assay, Mycobacterium Growth Indicator Tube (MGIT) culture, and solid culture using Löwenstein-Jensen (LJ) medium were used. The data were entered and analyzed using SPSS version 23, and a From a total of 308 participants enrolled in this study, the measured burdens of extrapulmonary tuberculosis using the Xpert MTB/RIF assay, liquid culture, and solid culture were 54 (17.5%), 45 (14.6%), and 39 (12.7%), respectively. In this study, sex, contact history with known TB cases, having a purulent type of aspirate, and being HIV positive had statistically significant associations with EPTB. The burden of extrapulmonary tuberculosis among presumptive extrapulmonary tuberculosis cases was found to be significant. Sex, contact history with a known TB case, having apurulent type of aspirate, and being HIV positive were found to be associated with extrapulmonary tuberculosis infection. Strict adherence to the national tuberculosis diagnosis and treatment guidelines is important, while the true burden of the disease should be ascertained using standard diagnostic tests for better prevention and control interventions.
Sections du résumé
Background
UNASSIGNED
Extra pulmonary tuberculosis (EPTB) accounts for a significant proportion of tuberculosis (TB), a devastating disease of public health concern. The complexity of the cases, the involvement of many organs, resource constraints, and concerns regarding drug resistance make disease diagnosis and treatment difficult. This study aimed to determine the burden of tuberculosis and associated factors among presumptive EPTB patients in selected hospitals in Addis Ababa.
Material and methods
UNASSIGNED
A cross-sectional study was conducted from February to August 2022 in selected public hospitals in Addis Ababa. Those who attended the hospitals and were presumptively diagnosed as EPTB patient were included in the study. Sociodemographic and clinical data were collected using a semistructured questionnaire. The GeneXpert MTB/RIF assay, Mycobacterium Growth Indicator Tube (MGIT) culture, and solid culture using Löwenstein-Jensen (LJ) medium were used. The data were entered and analyzed using SPSS version 23, and a
Results
UNASSIGNED
From a total of 308 participants enrolled in this study, the measured burdens of extrapulmonary tuberculosis using the Xpert MTB/RIF assay, liquid culture, and solid culture were 54 (17.5%), 45 (14.6%), and 39 (12.7%), respectively. In this study, sex, contact history with known TB cases, having a purulent type of aspirate, and being HIV positive had statistically significant associations with EPTB.
Conclusions
UNASSIGNED
The burden of extrapulmonary tuberculosis among presumptive extrapulmonary tuberculosis cases was found to be significant. Sex, contact history with a known TB case, having apurulent type of aspirate, and being HIV positive were found to be associated with extrapulmonary tuberculosis infection. Strict adherence to the national tuberculosis diagnosis and treatment guidelines is important, while the true burden of the disease should be ascertained using standard diagnostic tests for better prevention and control interventions.
Identifiants
pubmed: 37114203
doi: 10.1016/j.ijregi.2023.03.007
pii: S2772-7076(23)00033-4
pmc: PMC10127111
doi:
Types de publication
Journal Article
Langues
eng
Pagination
199-205Informations de copyright
© 2023 The Author(s).
Références
J Clin Microbiol. 1999 Nov;37(11):3578-82
pubmed: 10523555
Jpn J Infect Dis. 2013;66(4):263-8
pubmed: 23883834
BMC Infect Dis. 2015 Mar 03;15:112
pubmed: 25886866
J Infect Dev Ctries. 2012 Jan 12;6(1):53-7
pubmed: 22240429
Tuberc Respir Dis (Seoul). 2015 Apr;78(2):47-55
pubmed: 25861336
Int J Infect Dis. 2017 Mar;56:237-247
pubmed: 27838445
FEMS Immunol Med Microbiol. 2012 Oct;66(1):20-36
pubmed: 22574812
BMC Infect Dis. 2015 Oct 26;15:456
pubmed: 26503529
Infect Genet Evol. 2021 Nov;95:105052
pubmed: 34454121
PLoS One. 2016 Mar 07;11(3):e0150646
pubmed: 26950547
BMC Infect Dis. 2019 Dec 19;19(1):1069
pubmed: 31856744
PLoS One. 2019 Sep 16;14(9):e0222402
pubmed: 31525214
PLoS One. 2013 Dec 09;8(12):e81918
pubmed: 24349151
Eur Rev Med Pharmacol Sci. 2011 Apr;15(4):365-86
pubmed: 21608431
Biomed Res Int. 2018 Aug 07;2018:8207098
pubmed: 30159328