Generation of Haploid Spermatids on Silk Fibroin-Alginate-Laminin-Based Porous 3D Scaffolds.


Journal

Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941

Informations de publication

Date de publication:
09 2023
Historique:
revised: 03 04 2023
received: 29 12 2022
medline: 18 9 2023
pubmed: 28 4 2023
entrez: 28 4 2023
Statut: ppublish

Résumé

In vitro production of sperm is a desirable idea for fertility preservation in azoospermic men and prepubertal boys suffering from cancer. In this study, a biocompatible porous scaffold based on a triad mixture of silk fibroin (SF), alginate (Alg), and laminin (LM) is developed to facilitate the differentiation of mouse spermatogonia stem cells (SSCs). Following SF extraction, the content is analyzed by SDS-PAGE and stable porous 3D scaffolds are successfully prepared by merely Alg, SF, and a combination of Alg-SF, or Alg-SF-LM through freeze-drying. Then, the biomimetic scaffolds are characterized regarding the structural and biological properties, water absorption capacity, biocompatibility, biodegradability, and mechanical behavior. Neonatal mice testicular cells are seeded on three-dimensional scaffolds and their differentiation efficiency is evaluated using real-time PCR, flow cytometry, immunohistochemistry. Blend matrices showed uniform porous microstructures with interconnected networks, which maintained long-term stability and mechanical properties better than homogenous structures. Molecular analysis of the cells after 21 days of culture showed that the expression of differentiation-related proteins in cells that are developed in composite scaffolds is significantly higher than in other groups. The application of a composite system can lead to the differentiation of SSCs, paving the way for a novel infertility treatment landscape in the future.

Identifiants

pubmed: 37116215
doi: 10.1002/mabi.202200574
doi:

Substances chimiques

Fibroins 9007-76-5
Laminin 0
Alginates 0
Silk 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2200574

Informations de copyright

© 2023 Wiley-VCH GmbH.

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Auteurs

Zahra Bashiri (Z)

Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran.
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran.
Omid Fertility & Infertility Clinic, Hamedan, 6516796198, Iran.

Ali Moghaddaszadeh (A)

Departement of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran.

Reza Falak (R)

Immunology Research Center (IRC), Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, 1449614535, Iran.

Farnaz Khadivi (F)

Department of Anatomy, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, 8815713471, Iran.

Azita Afzali (A)

Hajar hospital, Shahrekord University of Medical Sciences, Shahrekord, 8816854633, Iran.

Mehdi Abbasi (M)

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417653761, Iran.

Ali Mohammad Sharifi (AM)

Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran.
Tissue Engineering Group (NOCERAL), Department of Orthopedics Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.

Hamid Reza Asgari (HR)

Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran.
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran.

Farid Ghanbari (F)

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran.

Morteza Koruji (M)

Stem cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran.
Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran.

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