Design, synthesis and biological evaluation of oxadiazole clubbed piperazine derivatives as potential antidepressant agents.
Antidepressant activity
Antioxidant
Benzylpiperazine
FST and TST
MAO inhibitors
Phenylpiperazine
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
29
11
2022
revised:
11
04
2023
accepted:
12
04
2023
medline:
29
5
2023
pubmed:
29
4
2023
entrez:
28
4
2023
Statut:
ppublish
Résumé
Piperazine derivatives have been of great interest to medicinal chemists in the development of antidepressant drugs due to their distinct molecular and structural features along with their pharmacological profile. In this study, we have designed and synthesized a series of 10 compounds of piperazine clubbed oxadiazole derivatives (5a-j) and screened for their MAO inhibitory activity. Compound 5f and 5 g were found to be the most potent MAO-A inhibitors of the series with IC
Identifiants
pubmed: 37116324
pii: S0045-2068(23)00204-3
doi: 10.1016/j.bioorg.2023.106544
pii:
doi:
Substances chimiques
Monoamine Oxidase Inhibitors
0
Antidepressive Agents
0
Monoamine Oxidase
EC 1.4.3.4
Piperazine
1RTM4PAL0V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106544Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.