Reconfiguration of brain network dynamics underlying spatial deficits in subjective cognitive decline.

Humans Magnetic Resonance Imaging / methods Brain / physiology Cognitive Dysfunction / psychology Brain Mapping / methods Probability
Brain dynamics Hidden Markov model Spatial navigation Subjective cognitive decline

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
07 2023
Historique:
received: 09 09 2022
revised: 12 02 2023
accepted: 06 03 2023
medline: 22 5 2023
pubmed: 29 4 2023
entrez: 28 4 2023
Statut: ppublish

Résumé

Brain dynamics and the associations with spatial navigation in individuals with subjective cognitive decline (SCD) remain unknown. In this study, a hidden Markov model (HMM) was inferred from resting-state functional magnetic resonance imaging data in a cohort of 80 SCD and 77 normal control (NC) participants. By HMM, 12 states with distinct brain activity were identified. The SCD group showed increased fractional occupancy in the states with less activated ventral default mode, posterior salience, and visuospatial networks, while decreased fractional occupancy in the state with general network activation. The SCD group also showed decreased probabilities of transition into and out of the state with general network activation, suggesting an inability to dynamically upregulate and downregulate brain network activity. Significant correlations between brain dynamics and spatial navigation were observed. The combined features of spatial navigation and brain dynamics showed an area under the curve of 0.854 in distinguishing between SCD and NC. The findings may provide exploratory evidence of the reconfiguration of brain network dynamics underlying spatial deficits in SCD.

Identifiants

DOI: 10.1016/j.neurobiolaging.2023.03.006 PMID: 37116409
pubmed: 37116409
pii: S0197-4580(23)00052-0
doi: 10.1016/j.neurobiolaging.2023.03.006
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-93

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Qian Chen (Q)

Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Futao Chen (F)

Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Yajing Zhu (Y)

Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Cong Long (C)

Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Jiaming Lu (J)

Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Xin Zhang (X)

Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Zuzana Nedelska (Z)

Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czechia.

Jakub Hort (J)

Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czechia.

Jun Chen (J)

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Guolin Ma (G)

Department of Radiology, China-Japan Friendship Hospital, Beijing, China.

Bing Zhang (B)

Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China; Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China; Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, China; Institute of Brain Science, Nanjing University, Nanjing, China. Electronic address: zhangbing_nanjing@nju.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reconfiguration of brain network dynamics...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Reconfiguration of brain network dynamics...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Reconfiguration of brain network dynamics...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Reconfiguration of brain network dynamics...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Reconfiguration of brain network dynamics...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Reconfiguration of brain network dynamics...