Epsin Mimetic UPI Peptide Delivery Strategies to Improve Endothelization of Vascular Grafts.
drug delivery
endothelial cell
epsin
fibrin
peptide
vascular graft
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
05
04
2023
medline:
18
9
2023
pubmed:
29
4
2023
entrez:
28
4
2023
Statut:
ppublish
Résumé
Endothelialization of engineered vascular grafts for replacement of small-diameter coronary arteries remains a critical challenge. The ability for an acellular vascular graft to promote endothelial cell (EC) recruitment in the body would be very beneficial. This study investigated epsins as a target since they are involved in internalization of vascular endothelial growth factor receptor 2. Specifically, epsin-mimetic UPI peptides are delivered locally from vascular grafts to block epsin activity and promote endothelialization. The peptide delivery from fibrin coatings allowed for controlled loading and provided a significant improvement in EC attachment, migration, and growth in vitro. The peptides have even more important impacts after grafting into rat abdominal aortae. The peptides prevented graft thrombosis and failure that is observed with a fibrin coating alone. They also modulated the in vivo remodeling. The grafts are able to remodel without the formation of a thick fibrous capsule on the adventitia with the 100 µg mL
Identifiants
pubmed: 37117010
doi: 10.1002/mabi.202300073
doi:
Substances chimiques
epsin
0
Vascular Endothelial Growth Factor A
0
Peptides
0
Fibrin
9001-31-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300073Informations de copyright
© 2023 Wiley-VCH GmbH.
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