A prospective whole-mixture approach to assess risk of the food and chemical exposome.
Journal
Nature food
ISSN: 2662-1355
Titre abrégé: Nat Food
Pays: England
ID NLM: 101761102
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
11
06
2020
accepted:
07
06
2021
medline:
1
7
2021
pubmed:
1
7
2021
entrez:
28
4
2023
Statut:
ppublish
Résumé
Many widely used chemicals result in ubiquitous human exposure from multiple sources, including diet. Legislation mainly deals with the toxicological evaluation of single substances owing to a methodological and conceptual lack of alternatives, and does so within defined silos subject to over 40 distinct regulations in the EU alone. Furthermore, much of the research and many of the initiatives concerned with the assessment and evaluation of chemical mixtures and their potential effects on human health rely on retrospective analysis. Here we propose an approach for the prospective identification, assessment and regulation of mixtures relevant to human health. We address two distinct aspects of toxicology-which chemicals actually do occur together, and how potential mixture-related health hazards can be predicted-with an adapted concept of the exposome and large-scale hazard screens. The proactive use of the likelihood of co-exposure, together with the new approach of methods-based testing, may be a timely and feasible way of identifying those substances and mixtures where hazards may have been overlooked and regulatory action is needed. Ideally, we would generate co-exposure patterns for specific consumer groups, depending on lifestyle and dietary habits, to assess the specific risk of identified mixtures.
Identifiants
pubmed: 37117676
doi: 10.1038/s43016-021-00316-7
pii: 10.1038/s43016-021-00316-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-468Informations de copyright
© 2021. Springer Nature Limited.
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