Microbiota from young mice counteracts selective age-associated behavioral deficits.

Animals Mice Microbiota Gastrointestinal Microbiome Fecal Microbiota Transplantation Aging / genetics Brain

Journal

Nature aging

ISSN: 2662-8465

Titre abrégé: Nat Aging

Pays: United States

ID NLM: 101773306

Informations de publication

Date de publication:
08 2021

Historique:

received: 27 10 2020

accepted: 25 06 2021

medline: 1 8 2021

pubmed: 1 8 2021

entrez: 28 4 2023

Statut: ppublish

Résumé

The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3-4 months) or old (19-20 months) donor mice into aged recipient mice (19-20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.

Identifiants

DOI: 10.1038/s43587-021-00093-9 PMID: 37117767

pubmed: 37117767

doi: 10.1038/s43587-021-00093-9

pii: 10.1038/s43587-021-00093-9

doi:

Types de publication

Research Support, Non-U.S. Gov't Letter

Langues

eng

Sous-ensembles de citation

Pagination

666-676

Commentaires et corrections

Type : CommentIn

Informations de copyright

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