Synthesis of lipid membranes for artificial cells.


Journal

Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631

Informations de publication

Date de publication:
Oct 2021
Historique:
accepted: 09 06 2021
medline: 1 10 2021
pubmed: 1 10 2021
entrez: 28 4 2023
Statut: ppublish

Résumé

A major goal of synthetic biology is to understand the transition between non-living matter and life. The bottom-up development of an artificial cell would provide a minimal system with which to study the border between chemistry and biology. So far, a fully synthetic cell has remained elusive, but chemists are progressing towards this goal by reconstructing cellular subsystems. Cell boundaries, likely in the form of lipid membranes, were necessary for the emergence of life. In addition to providing a protective barrier between cellular cargo and the external environment, lipid compartments maintain homeostasis with other subsystems to regulate cellular processes. In this Review, we examine different chemical approaches to making cell-mimetic compartments. Synthetic strategies to drive membrane formation and function, including bioorthogonal ligations, dissipative self-assembly and reconstitution of biochemical pathways, are discussed. Chemical strategies aim to recreate the interactions between lipid membranes, the external environment and internal biomolecules, and will clarify our understanding of life at the interface of chemistry and biology.

Identifiants

pubmed: 37118179
doi: 10.1038/s41570-021-00303-3
pii: 10.1038/s41570-021-00303-3
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

676-694

Informations de copyright

© 2021. Springer Nature Limited.

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Auteurs

Kira A Podolsky (KA)

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.

Neal K Devaraj (NK)

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. ndevaraj@ucsd.edu.

Classifications MeSH