Towards the sustainable discovery and development of new antibiotics.
Journal
Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
accepted:
01
07
2021
medline:
1
10
2021
pubmed:
1
10
2021
entrez:
28
4
2023
Statut:
ppublish
Résumé
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
Identifiants
pubmed: 37118182
doi: 10.1038/s41570-021-00313-1
pii: 10.1038/s41570-021-00313-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
726-749Informations de copyright
© 2021. Springer Nature Limited.
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