Towards the sustainable discovery and development of new antibiotics.


Journal

Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631

Informations de publication

Date de publication:
Oct 2021
Historique:
accepted: 01 07 2021
medline: 1 10 2021
pubmed: 1 10 2021
entrez: 28 4 2023
Statut: ppublish

Résumé

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.

Identifiants

pubmed: 37118182
doi: 10.1038/s41570-021-00313-1
pii: 10.1038/s41570-021-00313-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

726-749

Informations de copyright

© 2021. Springer Nature Limited.

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Auteurs

Marcus Miethke (M)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
German Center for Infection Research (DZIF), Braunschweig, Germany.

Marco Pieroni (M)

Food and Drug Department, University of Parma, Parma, Italy.

Tilmann Weber (T)

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.

Mark Brönstrup (M)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Department of Chemical Biology (CBIO), Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.

Peter Hammann (P)

Infectious Diseases & Natural Product Research at EVOTEC, and Justus Liebig University Giessen, Giessen, Germany.

Ludovic Halby (L)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, UMR n°3523, CNRS, Paris, France.

Paola B Arimondo (PB)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, UMR n°3523, CNRS, Paris, France.

Philippe Glaser (P)

Ecology and Evolution of Antibiotic Resistance Unit, Microbiology Department, Institut Pasteur, CNRS UMR3525, Paris, France.

Bertrand Aigle (B)

Université de Lorraine, INRAE, DynAMic, Nancy, France.

Helge B Bode (HB)

Department of Biosciences, Goethe University Frankfurt, Frankfurt, Germany.
Max Planck Institute for Terrestrial Microbiology, Department of Natural Products in Organismic Interactions, Marburg, Germany.

Rui Moreira (R)

Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.

Yanyan Li (Y)

Unit MCAM, CNRS, National Museum of Natural History (MNHN), Paris, France.

Andriy Luzhetskyy (A)

Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.

Marnix H Medema (MH)

Bioinformatics Group, Wageningen University and Research, Wageningen, Netherlands.

Jean-Luc Pernodet (JL)

Institute for Integrative Biology of the Cell (I2BC) & Microbiology Department, University of Paris-Saclay, Gif-sur-Yvette, France.

Marc Stadler (M)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Microbial Drugs (MWIS), Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.

José Rubén Tormo (JR)

Fundación MEDINA, Granada, Spain.

Olga Genilloud (O)

Fundación MEDINA, Granada, Spain.

Andrew W Truman (AW)

Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.

Kira J Weissman (KJ)

Molecular and Structural Enzymology Group, Université de Lorraine, CNRS, IMoPA, Nancy, France.

Eriko Takano (E)

Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom.

Stefano Sabatini (S)

Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.

Evi Stegmann (E)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.

Heike Brötz-Oesterhelt (H)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.

Wolfgang Wohlleben (W)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Department of Microbiology/Biotechnology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.

Myriam Seemann (M)

Institute for Chemistry UMR 7177, University of Strasbourg/CNRS, ITI InnoVec, Strasbourg, France.

Martin Empting (M)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
German Center for Infection Research (DZIF), Braunschweig, Germany.

Anna K H Hirsch (AKH)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
German Center for Infection Research (DZIF), Braunschweig, Germany.

Brigitta Loretz (B)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.

Claus-Michael Lehr (CM)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.

Alexander Titz (A)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
German Center for Infection Research (DZIF), Braunschweig, Germany.

Jennifer Herrmann (J)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
German Center for Infection Research (DZIF), Braunschweig, Germany.

Timo Jaeger (T)

German Center for Infection Research (DZIF), Braunschweig, Germany.

Silke Alt (S)

German Center for Infection Research (DZIF), Braunschweig, Germany.

Thomas Hesterkamp (T)

German Center for Infection Research (DZIF), Braunschweig, Germany.

Mathias Winterhalter (M)

Life Sciences & Chemistry, Jacobs University Bremen, Bremen, Germany.

Andrea Schiefer (A)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Kenneth Pfarr (K)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Achim Hoerauf (A)

German Center for Infection Research (DZIF), Braunschweig, Germany.
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Heather Graz (H)

Biophys Ltd., Usk, Monmouthshire, United Kingdom.

Michael Graz (M)

School of Law, University of Bristol, Bristol, United Kingdom.

Mika Lindvall (M)

Recursion Pharmaceuticals, Salt Lake City, UT, USA.

Savithri Ramurthy (S)

Drug Discovery/Medicinal Chemistry, HiberCell, New York, NY, USA.

Anders Karlén (A)

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Maarten van Dongen (M)

AMR Insights, Amsterdam, Netherlands.

Hrvoje Petkovic (H)

Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Andreas Keller (A)

Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany.

Frédéric Peyrane (F)

BEAM Alliance, Paris, France.

Stefano Donadio (S)

NAICONS Srl, Milan, Italy.

Laurent Fraisse (L)

Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.

Laura J V Piddock (LJV)

The Global Antibiotic Research and Development Partnership (GARDP), Geneva, Switzerland.

Ian H Gilbert (IH)

Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

Heinz E Moser (HE)

Novartis Institutes for BioMedical Research (NIBR), Emeryville, CA, USA. heinz.moser@novartis.com.

Rolf Müller (R)

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany. rolf.mueller@helmholtz-hips.de.
German Center for Infection Research (DZIF), Braunschweig, Germany. rolf.mueller@helmholtz-hips.de.

Classifications MeSH