Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species.
Journal
Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
09
10
2020
accepted:
27
09
2021
medline:
1
5
2023
pubmed:
1
11
2021
entrez:
28
4
2023
Statut:
ppublish
Résumé
To identify candidate bacteria associated with aging, we performed fecal microbiota sequencing in young, middle-aged and older adults, and found lower Bifidobacterium adolescentis abundance in older individuals aged ≥60 years. Dietary supplementation of B. adolescentis improved osteoporosis and neurodegeneration in a mouse model of premature aging (Terc
Identifiants
pubmed: 37118342
doi: 10.1038/s43587-021-00129-0
pii: 10.1038/s43587-021-00129-0
doi:
Substances chimiques
Catalase
EC 1.11.1.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
991-1001Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
Références
Bana, B. & Cabreiro, F. The microbiome and aging. Annu. Rev. Genet. 53, 239–261 (2019).
pubmed: 31487470
doi: 10.1146/annurev-genet-112618-043650
Obata, F., Fons, C. O. & Gould, A. P. Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila. Nat. Commun. 9, 975 (2018).
pubmed: 29515102
pmcid: 5841413
doi: 10.1038/s41467-018-03070-w
Biagi, E. et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE 5, e10667 (2010).
pubmed: 20498852
pmcid: 2871786
doi: 10.1371/journal.pone.0010667
Barcena, C. et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat. Med. 25, 1234–1242 (2019).
pubmed: 31332389
doi: 10.1038/s41591-019-0504-5
Wang, F. et al. Gut microbiota community and its assembly associated with age and diet in Chinese centenarians. J. Microbiol. Biotechnol. 25, 1195–1204 (2015).
pubmed: 25839332
doi: 10.4014/jmb.1410.10014
Kim, B. S. et al. Comparison of the gut microbiota of centenarians in longevity villages of South Korea with those of other age groups. J. Microbiol. Biotechnol. 29, 429–440 (2019).
pubmed: 30661321
doi: 10.4014/jmb.1811.11023
Koh, A., De Vadder, F., Kovatcheva-Datchary, P. & Backhed, F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165, 1332–1345 (2016).
pubmed: 27259147
doi: 10.1016/j.cell.2016.05.041
Ruiz-Ruiz, S. et al. Functional microbiome deficits associated with ageing: chronological age threshold. Aging Cell 19, e13063 (2020).
pubmed: 31730262
doi: 10.1111/acel.13063
Duranti, S. et al. Bifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA. Sci. Rep. 10, 14112 (2020).
pubmed: 32839473
pmcid: 7445748
doi: 10.1038/s41598-020-70986-z
Fan, L. et al. B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling. Gut Microbes 13, 1826746 (2021).
pmcid: 7889144
doi: 10.1080/19490976.2020.1826746
Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25–34 (1997).
pubmed: 9335332
doi: 10.1016/S0092-8674(01)80006-4
Roberts, A. R. et al. Non-telomeric epigenetic and genetic changes are associated with the inheritance of shorter telomeres in mice. Chromosoma 122, 541–554 (2013).
pubmed: 23864360
doi: 10.1007/s00412-013-0427-8
Perez-Rivero, G. et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation 114, 309–317 (2006).
pubmed: 16831983
doi: 10.1161/CIRCULATIONAHA.105.611111
Bernardes de Jesus, B. et al. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 10, 604–621 (2011).
pubmed: 21426483
doi: 10.1111/j.1474-9726.2011.00700.x
Whitehead, J. C. et al. A clinical frailty index in aging mice: comparisons with frailty index data in humans. J. Gerontol. A Biol. Sci. Med. Sci. 69, 621–632 (2014).
pubmed: 24051346
doi: 10.1093/gerona/glt136
McHugh, D. & Gil, J. Senescence and aging: causes, consequences, and therapeutic avenues. J. Cell Biol. 217, 65–77 (2018).
pubmed: 29114066
pmcid: 5748990
doi: 10.1083/jcb.201708092
Kritsilis, M. et al. Ageing, Cellular senescence and neurodegenerative disease. Int. J. Mol. Sci. 19, 2937 (2018).
pmcid: 6213570
doi: 10.3390/ijms19102937
Kundu, P., Blacher, E., Elinav, E. & Pettersson, S. Our gut microbiome: the evolving inner self. Cell 171, 1481–1493 (2017).
pubmed: 29245010
doi: 10.1016/j.cell.2017.11.024
Zhang, R. & Hou, A. Host–microbe interactions in Caenorhabditis elegans. ISRN Microbiol. 2013, 356451 (2013).
pubmed: 23984180
pmcid: 3747393
doi: 10.1155/2013/356451
Kumar, A. et al. Caenorhabditis elegans: a model to understand host-microbe interactions. Cell Mol. Life Sci. 77, 1229–1249 (2020).
pubmed: 31584128
doi: 10.1007/s00018-019-03319-7
Ren, C., Webster, P., Finkel, S. E. & Tower, J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 6, 144–152 (2007).
pubmed: 17681150
doi: 10.1016/j.cmet.2007.06.006
MacNeil, L. T., Watson, E., Arda, H. E., Zhu, L. J. & Walhout, A. J. Diet-induced developmental acceleration independent of TOR and insulin in C. elegans. Cell 153, 240–252 (2013).
pubmed: 23540701
doi: 10.1016/j.cell.2013.02.049
Garsin, D. A. et al. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300, 1921 (2003).
pubmed: 12817143
doi: 10.1126/science.1080147
Nakagawa, H. et al. Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans. Aging Cell 15, 227–236 (2016).
pubmed: 26710940
doi: 10.1111/acel.12431
Xiao, C. & Robertson, R. M. Locomotion induced by spatial restriction in adult Drosophila. PLoS ONE 10, e0135825 (2015).
pubmed: 26351842
pmcid: 4564261
doi: 10.1371/journal.pone.0135825
Pomatto, L. C. D., Wong, S., Tower, J. & Davies, K. J. A. Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. Arch. Biochem. Biophys. 636, 57–70 (2017).
pubmed: 29100984
pmcid: 6508965
doi: 10.1016/j.abb.2017.10.021
Duneau, D. F. et al. The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila. BMC Biol. 15, 124 (2017).
pubmed: 29268741
pmcid: 5740927
doi: 10.1186/s12915-017-0466-3
Davalli, P., Mitic, T., Caporali, A., Lauriola, A. & D’Arca, D. ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases. Oxid. Med. Cell Longev. 2016, 3565127 (2016).
pubmed: 27247702
pmcid: 4877482
doi: 10.1155/2016/3565127
Li, P. et al. In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food Funct. 5, 50–56 (2014).
pubmed: 24232123
doi: 10.1039/C3FO60273G
Altinoz, M. A. & Ozpinar, A. PPAR-delta and erucic acid in multiple sclerosis and Alzheimer’s disease. Likely benefits in terms of immunity and metabolism. Int. Immunopharmacol. 69, 245–256 (2019).
pubmed: 30738994
doi: 10.1016/j.intimp.2019.01.057
Kim, E. et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol. Biochem. Behav. 142, 85–90 (2016).
pubmed: 26780350
doi: 10.1016/j.pbb.2016.01.006
Li, J. et al. Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling. J. Ethnopharmacol. 257, 112796 (2020).
pubmed: 32344236
doi: 10.1016/j.jep.2020.112796
Hao, S. et al. Hydroxycinnamic acid from corncob and its structural analogues inhibit Abeta40 fibrillation and attenuate Abeta40-induced cytotoxicity. J. Agric. Food Chem. 68, 8788–8796 (2020).
pubmed: 32700906
doi: 10.1021/acs.jafc.0c01841
Wu, K. C., Chiang, B. J., Tsai, W. H., Chung, S. D. & Chien, C. T. I-Tiao-Gung extract through its active component daidzin improves cyclophosphamide-induced bladder dysfunction in rat model. Neurourol. Urodyn. 37, 2560–2570 (2018).
pubmed: 30252154
doi: 10.1002/nau.23815
Stoyanova, S., Geuns, J., Hideg, E., & Van den Ende, W. The food additives inulin and stevioside counteract oxidative stress. Int. J. Food Sci. Nutr. 62, 207–214 (2020).
doi: 10.3109/09637486.2010.523416
Quinlan, G. J., Lamb, N. J., Tilley, R., Evans, T. W. & Gutteridge, J. M. Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality. Am. J. Respir. Crit. Care Med. 155, 479–484 (1997).
pubmed: 9032182
doi: 10.1164/ajrccm.155.2.9032182
Yamada, S. et al. Cholic acid enhances visceral adiposity, atherosclerosis and nonalcoholic fatty liver disease in microminipigs. J. Atheroscler. Thromb. 24, 1150–1166 (2017).
pubmed: 28496045
pmcid: 5684480
doi: 10.5551/jat.39909
Apaya, M. K. et al. Simvastatin and a plant galactolipid protect animals from septic shock by regulating oxylipin mediator dynamics through the MAPK-cPLA2 signaling pathway. Mol. Med. 21, 988–1001 (2015).
doi: 10.2119/molmed.2015.00082
Rombouts, C. et al. Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites. Sci. Rep. 7, 42514 (2017).
pubmed: 28195169
pmcid: 5307356
doi: 10.1038/srep42514
Drouin, N. et al. Electromembrane extraction of highly polar compounds: analysis of cardiovascular biomarkers in plasma. Metabolites 10, 4 (2020).
doi: 10.3390/metabo10010004
Min, Z. et al. Cosmosiin increases ADAM10 expression via mechanisms Involving 5'UTR and PI3K signaling. Front. Mol. Neurosci. 11, 198 (2018).
pubmed: 29942252
pmcid: 6004422
doi: 10.3389/fnmol.2018.00198
Shin, M. K., Jeon, Y. D. & Jin, J. S. Apoptotic effect of enterodiol, the final metabolite of edible lignans, in colorectal cancer cells. J. Sci. Food Agric. 99, 2411–2419 (2019).
pubmed: 30357838
doi: 10.1002/jsfa.9448
Biragyn, A. & Ferrucci, L. Gut dysbiosis: a potential link between increased cancer risk in ageing and inflammaging. Lancet Oncol. 19, e295–e304 (2018).
pubmed: 29893261
pmcid: 6047065
doi: 10.1016/S1470-2045(18)30095-0
Moya, A. & Ferrer, M. Functional redundancy-induced stability of gut microbiota subjected to disturbance. Trends Microbiol. 24, 402–413 (2016).
pubmed: 26996765
doi: 10.1016/j.tim.2016.02.002
Kundu, P. et al. Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. Sci. Transl. Med. 11, eaau4760 (2019).
pubmed: 31723038
doi: 10.1126/scitranslmed.aau4760
Sherwin, E., Bordenstein, S. R., Quinn, J. L., Dinan, T. G. & Cryan, J. F. Microbiota and the social brain. Science 366, eaar2016 (2019).
pubmed: 31672864
doi: 10.1126/science.aar2016
Li, L. et al. Microbial osteoporosis: the interplay between the gut microbiota and bones via host metabolism and immunity. Microbiologyopen 8, e00810 (2019).
pubmed: 31001921
pmcid: 6692530
doi: 10.1002/mbo3.810
Biver, E. et al. Gut microbiota and osteoarthritis management: an expert consensus of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Ageing Res. Rev. 55, 100946 (2019).
pubmed: 31437484
doi: 10.1016/j.arr.2019.100946
Forslund, K. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262–266 (2015).
pubmed: 26633628
pmcid: 4681099
doi: 10.1038/nature15766
Caussy, C. & Loomba, R. Gut microbiome, microbial metabolites and the development of NAFLD. Nat. Rev. Gastroenterol. Hepatol. 15, 719–720 (2018).
pubmed: 30158571
doi: 10.1038/s41575-018-0058-x
Henao-Mejia, J. et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179–185 (2012).
pubmed: 22297845
pmcid: 3276682
doi: 10.1038/nature10809
Tang, W. H. W., Backhed, F., Landmesser, U. & Hazen, S. L. Intestinal microbiota in cardiovascular health and disease: JACC state-of-the-art review. J. Am. Coll. Cardiol. 73, 2089–2105 (2019).
pubmed: 31023434
pmcid: 6518422
doi: 10.1016/j.jacc.2019.03.024
Wang, S. et al. Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. Geroscience 42, 333–352 (2020).
pubmed: 31814084
doi: 10.1007/s11357-019-00137-4
Han, B. et al. Microbial genetic composition tunes host longevity. Cell 169, 1249–1262,e1213 (2017).
pubmed: 28622510
pmcid: 5635830
doi: 10.1016/j.cell.2017.05.036
Petriv, O. I. & Rachubinski, R. A. Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. J. Biol. Chem. 279, 19996–20001 (2004).
pubmed: 14996832
doi: 10.1074/jbc.M400207200
Lee, K. A. et al. Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila. Cell 153, 797–811 (2013).
pubmed: 23663779
doi: 10.1016/j.cell.2013.04.009
Vaccaro, A. et al. Sleep loss can cause death through accumulation of reactive oxygen species in the gut. Cell 181, 1307–1328.e1315 (2020).
pubmed: 32502393
doi: 10.1016/j.cell.2020.04.049
Ackman, R. G., Eaton, C. A. & Dyerberg, J. Marine docosenoic acid isomer distribution in the plasma of Greenland Eskimos. Am. J. Clin. Nutr. 33, l814–l817 (1980).
pubmed: 7190776
doi: 10.1093/ajcn/33.8.1814
Sinclair, H. Erucic acid and the Spanish oil epidemic. Lancet 2, 1293 (1981).
pubmed: 6118706
doi: 10.1016/S0140-6736(81)91533-6
Altinoz, M. A., Ozpinar, A., Ozpinar, A. & Hacker, E. Erucic acid, a nutritional PPARdelta-ligand may influence Huntington’s disease pathogenesis. Metab. Brain Dis. 35, 1–9 (2020).
pubmed: 31625071
doi: 10.1007/s11011-019-00500-6
Wei, G. et al. Daidzin inhibits RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced bone loss in vivo. J. Cell Biochem. 120, 5304–5314 (2019).
pubmed: 30378146
doi: 10.1002/jcb.27806
Chen, L. et al. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: an open-label, randomized clinical trial. EBioMedicine 35, 87–96 (2018).
pubmed: 30145102
pmcid: 6161473
doi: 10.1016/j.ebiom.2018.08.028
Wu, S. et al. GMrepo: a database of curated and consistently annotated human gut metagenomes. Nucleic Acids Res. 48, D545–D553 (2020).
pubmed: 31504765
doi: 10.1093/nar/gkz764
Iatsenko, I., Boquete, J. P. & Lemaitre, B. Microbiota-derived lactate activates production of reactive oxygen species by the intestinal NADPH oxidase Nox and shortens Drosophila lifespan. Immunity 49, 929–942,e925 (2018).
pubmed: 30446385
doi: 10.1016/j.immuni.2018.09.017
Fast, D., Duggal, A. & Foley, E. Monoassociation with Lactobacillus plantarum disrupts intestinal homeostasis in adult Drosophila melanogaster. mBio 9, e01114–18 (2018).
pubmed: 30065090
pmcid: 6069112
doi: 10.1128/mBio.01114-18
Komura, T., Ikeda, T., Yasui, C., Saeki, S. & Nishikawa, Y. Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans. Biogerontol. 14, 73–87 (2013).
doi: 10.1007/s10522-012-9411-6
Guo, T. et al. The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis. J. Biol. Chem. 294, 5666–5676 (2019).
pubmed: 30760524
pmcid: 6462509
doi: 10.1074/jbc.RA118.006069
Hosono, R., Sato, Y., Aizawa, S. I. & Mitsui, Y. Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans. Exp. Gerontol. 15, 285–289 (1980).
pubmed: 7409025
doi: 10.1016/0531-5565(80)90032-7
Herndon, L. A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808–814 (2002).
pubmed: 12397350
doi: 10.1038/nature01135