Canonical fibroblast growth factors in viral infection.
fibroblast growth factor
inflammation
viral infection
Journal
Reviews in medical virology
ISSN: 1099-1654
Titre abrégé: Rev Med Virol
Pays: England
ID NLM: 9112448
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
13
04
2023
received:
14
03
2023
accepted:
24
04
2023
medline:
10
7
2023
pubmed:
29
4
2023
entrez:
29
4
2023
Statut:
ppublish
Résumé
Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in the development and maintenance of various tissues in the body. There are three function-al groups of FGFs: canonical FGFs (cFGFs), intracellularly retained FGFs, and metabolic (also called endocrine) FGFs. cFGFs are secreted and act in an autocrine/paracrine fashion to regulate differentiation during foetal development, as well as tissue repair in adults. Recent studies have also begun to unravel the role of cFGFs during viral infections, suggesting that FGF-2 and other canonical FGFs may have an important virus-specific role, also by the regulation of the immune response. Because dysregulation in the FGF pathways is pivotal in cancer development, FGFs are the target of many anticancer drugs. These drugs may be repurposed to treat viral infection, since dysregulation of FGF signalling has been implicated in the pathogenesis of viral infections, such as hepatitis C. Overall, the role of cFGFs during viral infection is an underrepresented area of current research. This review focuses on overviewing the effects of canonical FGFs during infection by different viruses. Many studies highlight that the effects of FGFs during viral infection may be complex and context-dependent. While there is evidence to suggest that FGFs may have a beneficial impact on the immune response and tissue repair during viral infection, further studies are needed to fully understand the mechanisms underlying these effects and to determine in what cases FGFs could be targeted as a therapeutic approach for viral infection.
Substances chimiques
Fibroblast Growth Factors
62031-54-3
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2452Subventions
Organisme : Progetto di Ricerca di Ateneo 2020, PRA_2020_32 and PRA_2020_37 of the University of Pisa
Organisme : Ministry of University and Research PNRR - Tuscany Health Ecosystem - CUP I53C22000780001 - Project code ECS00000017- spoke n. 7- "Innovating Translational Medicine".
Organisme : Progetti di Ricerca di Rilevante Interesse Nazionale PRIN 2020, Prot. n. 2020KSY3KL
Organisme : H2020-FETOPEN-2018-2020, Proposal ID 862714
Informations de copyright
© 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.
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