Perfusion-Dependent Focal Neurologic Deficits in a Critically Ill Heart Transplant Recipient: A Case of Tacrolimus-Associated Reversible Cerebral Vasospasm Syndrome?

Humans Tacrolimus / adverse effects Vasospasm, Intracranial / chemically induced Posterior Leukoencephalopathy Syndrome / chemically induced Critical Illness Perfusion / adverse effects Heart Transplantation / adverse effects
orthotopic heart transplant posterior reversible encephalopathy syndrome reversible cerebral vasospasm syndrome reversible posterior leukoencephalopathy syndrome tacrolimus

Journal

Journal of cardiothoracic and vascular anesthesia
ISSN: 1532-8422
Titre abrégé: J Cardiothorac Vasc Anesth
Pays: United States
ID NLM: 9110208

Informations de publication

Date de publication:
08 2023
Historique:
received: 26 03 2023
accepted: 30 03 2023
medline: 28 6 2023
pubmed: 30 4 2023
entrez: 29 4 2023
Statut: ppublish

Résumé

TACROLIMUS, a mainstay of immunosuppression after orthotopic heart transplantation (OHT), is associated with a broad range of side effects. Vasoconstriction caused by tacrolimus has been proposed as a mechanism underlying common side effects such as hypertension and renal injury. Neurologic side effects attributed to tacrolimus include headaches, posterior reversible encephalopathy syndrome (PRES), or reversible cerebral vasospasm syndrome (RCVS). Six case reports have been published describing RCVS in the setting of tacrolimus administration after OHT. The authors report a case of perfusion-dependent focal neurologic deficits attributed to tacrolimus-induced RCVS in an OHT recipient.

Identifiants

DOI: 10.1053/j.jvca.2023.03.044 PMID: 37120321
pubmed: 37120321
pii: S1053-0770(23)00235-5
doi: 10.1053/j.jvca.2023.03.044
pii:
doi:

Substances chimiques

Tacrolimus WM0HAQ4WNM

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1487-1494

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of Interest None.

Auteurs

Jamie Bloom (J)

Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, PA.

Micaela Langille Collins (ML)

Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA.

Mia P Belovsky (MP)

Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.

Eric Feduska (E)

Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, PA.

Patrick Schofield (P)

Lehigh Valley Healthcare Network, Allentown, PA.

Ron Leong (R)

Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, PA.

John G Augoustides (JG)

Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA.

Ilya Lembrikov (I)

Department of Anesthesiology, Sheba Medical Center-Tel HaShomer, Ramat Gan, Israel.

Alexander Kogan (A)

Department of Cardiac Surgery, Sheba Medical Center-Tel HaShomer, Ramat Gan, Israel.

Jonathan Frogel (J)

Department of Anesthesiology, Sheba Medical Center-Tel HaShomer, Ramat Gan, Israel.

Karuna Puttur Rajkumar (KP)

Department of Anesthesiology, Cardiothoracic and Critical Care Sections, Wake Forest University School of Medicine, Winston Salem, NC.

Megan H Hicks (MH)

Department of Anesthesiology, Cardiothoracic and Critical Care Sections, Wake Forest University School of Medicine, Winston Salem, NC.

Rohesh J Fernando (RJ)

Department of Anesthesiology, Cardiothoracic Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC. Electronic address: rfernan@wakehealth.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tacrolimus › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Vasospasme intracrânien › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Leucoencéphalopathies › Leucoencéphalopathie postérieure › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Perfusion-Dependent Focal Neurologic Deficits...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Transplantation cardiaque › Perfusion-Dependent Focal Neurologic Deficits...