Use of the neutrophil-to-lymphocyte ratio and an oxygen requirement to predict disease severity in patients with COVID-19.

Humans COVID-19 SARS-CoV-2 Neutrophils Oxygen Retrospective Studies Lymphocytes Patient Acuity
Area under the curve COVID-19 Neutrophil-to-lymphocyte ratio Prognostic indicator SARS-CoV-2

Journal

Respiratory investigation
ISSN: 2212-5353
Titre abrégé: Respir Investig
Pays: Netherlands
ID NLM: 101581124

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 20 10 2022
revised: 08 02 2023
accepted: 06 03 2023
medline: 19 6 2023
pubmed: 1 5 2023
entrez: 30 4 2023
Statut: ppublish

Résumé

We investigated the association between complete blood count, including neutrophil-to-lymphocyte ratio (NLR) in combination with patient characteristics, and coronavirus disease (COVID-19) outcomes to identify the best prognostic indicator. We analyzed data of patients with confirmed COVID-19 from the nationwide database of the Japan COVID-19 Task Force between February 2020 and November 2021. A composite outcome was defined as the most severe condition, including noninvasive positive-pressure ventilation, high-flow nasal cannula, invasive mechanical ventilation, extracorporeal membrane oxygenation, or death. Of 2425 patients in the analysis, 472 (19.5%) experienced a composite outcome. NLR was the best predictor of composite outcomes, with an area under the curve (AUC) of 0.81, and a sensitivity and specificity of 72.3% and 75.7%, respectively, using a cut-off value of 5.04. The combination of NLR and an oxygen requirement on admission had the highest AUC (0.88). This simple combination may help identify patients at risk of progression to severe disease.

Identifiants

DOI: 10.1016/j.resinv.2023.03.007 PMID: 37121116 PMC: PMC10113601
pubmed: 37121116
pii: S2212-5345(23)00037-0
doi: 10.1016/j.resinv.2023.03.007
pmc: PMC10113601
pii:
doi:

Substances chimiques

Oxygen S88TT14065

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

454-459

Informations de copyright

Copyright © 2023 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of Interest The authors have no conflicts of interest.

Auteurs

Takuya Ozawa (T)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Takanori Asakura (T)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan. Electronic address: takanori.asakura@keio.jp.

Shotaro Chubachi (S)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Ho Namkoong (H)

Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Hiromu Tanaka (H)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Ko Lee (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Takahiro Fukushima (T)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Shiro Otake (S)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Kensuke Nakagawara (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Mayuko Watase (M)

Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Katsunori Masaki (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Hirofumi Kamata (H)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Makoto Ishii (M)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Naoki Hasegawa (N)

Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Norihiro Harada (N)

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.

Tetsuya Ueda (T)

Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.

Soichiro Ueda (S)

JCHO (Japan Community Health Care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.

Takashi Ishiguro (T)

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.

Ken Arimura (K)

Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.

Fukuki Saito (F)

Department of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.

Takashi Yoshiyama (T)

Fukujuji Hospital, Kiyose, Japan.

Yasushi Nakano (Y)

Kawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.

Yoshikazu Mutoh (Y)

Department of Infectious Diseases, Tosei General Hospital, Seto, Japan.

Yusuke Suzuki (Y)

Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan; Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan.

Ryuya Edahiro (R)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.

Koji Murakami (K)

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; The Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.

Ryuji Koike (R)

Medical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.

Yuko Kitagawa (Y)

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Katsushi Tokunaga (K)

Genome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.

Akinori Kimura (A)

Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.

Seiya Imoto (S)

Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Satoru Miyano (S)

M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.

Seishi Ogawa (S)

Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.

Takanori Kanai (T)

Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Koichi Fukunaga (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Use of the neutrophil-to-lymphocyte ratio and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Use of the neutrophil-to-lymphocyte ratio and...