Stretching Peptides to Generate Small Molecule β-Strand Mimics.
Journal
ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035
Informations de publication
Date de publication:
26 Apr 2023
26 Apr 2023
Historique:
received:
07
12
2022
medline:
1
5
2023
pubmed:
1
5
2023
entrez:
1
5
2023
Statut:
epublish
Résumé
Advances in the modulation of protein-protein interactions (PPIs) enable both characterization of PPI networks that govern diseases and design of therapeutics and probes. The shallow protein surfaces that dominate PPIs are challenging to target using standard methods, and approaches for accessing extended backbone structures are limited. Here, we incorporate a rigid, linear, diyne brace between side chains at the
Identifiants
pubmed: 37122474
doi: 10.1021/acscentsci.2c01462
pmc: PMC10141592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
648-656Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM069832
Pays : United States
Informations de copyright
© 2023 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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