A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.
BGT-1
GABA
GAT1
SLC6 neurotransmitter transporters
structure-function
transporter
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
01
2023
accepted:
30
03
2023
medline:
1
5
2023
pubmed:
1
5
2023
entrez:
1
5
2023
Statut:
epublish
Résumé
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Its homeostasis is maintained by neuronal and glial GABA transporters (GATs). The four GATs identified in humans are GAT1 (SLC6A1), GAT2 (SLC6A13), GAT3 (SLC6A11), and betaine/GABA transporter-1 BGT-1 (SLC6A12) which are all members of the solute carrier 6 (SLC6) family of sodium-dependent transporters. While GAT1 has been investigated extensively, the other GABA transporters are less studied and their role in CNS is not clearly defined. Altered GABAergic neurotransmission is involved in different diseases, but the importance of the different transporters remained understudied and limits drug targeting. In this review, the well-studied GABA transporter GAT1 is compared with the less-studied BGT-1 with the aim to leverage the knowledge on GAT1 to shed new light on the open questions concerning BGT-1. The most recent knowledge on transporter structure, functions, expression, and localization is discussed along with their specific role as drug targets for neurological and neurodegenerative disorders. We review and discuss data on the binding sites for Na
Identifiants
pubmed: 37123280
doi: 10.3389/fphys.2023.1145973
pii: 1145973
pmc: PMC10137170
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1145973Informations de copyright
Copyright © 2023 Bhatt, Gauthier-Manuel, Lazzarin, Zerlotti, Ziegler, Bazzone, Stockner and Bossi.
Déclaration de conflit d'intérêts
AB and RZ were employed by Nanion technologies GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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