Cardiac MRI-derived Extracellular Volume Fraction versus Myocardium-to-Lumen R1 Ratio at Postcontrast T1 Mapping for Detecting Cardiac Amyloidosis.

Cardiac Cardiomyopathies Heart MR Imaging

Journal

Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 26 12 2022
revised: 02 03 2023
accepted: 14 03 2023
medline: 1 5 2023
pubmed: 1 5 2023
entrez: 1 5 2023
Statut: epublish

Résumé

To evaluate the diagnostic performance of myocardium-to-lumen R1 (1/T1) ratio on postcontrast T1 maps for the detection of cardiac amyloidosis in a large patient sample. This retrospective study included consecutive patients who underwent MRI-derived extracellular volume fraction (MRI ECV) analysis between March 2017 and July 2021 because of known or suspected heart failure or cardiomyopathy. Pre- and postcontrast T1 maps were generated using the modified Look-Locker inversion recovery sequence. Diagnostic performances of MRI ECV and myocardium-to-lumen R1 ratio on postcontrast T1 maps (a simplified index not requiring a native T1 map and hematocrit level data) for detecting cardiac amyloidosis were evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. Of 352 patients (mean age, 63 years ± 16 [SD]; 235 men), 136 had cardiac amyloidosis. MRI ECV showed 89.0% (121 of 136; 95% CI: 82%, 94%) sensitivity and 98.6% (213 of 216; 95% CI: 96%, 100%) specificity for helping detect cardiac amyloidosis (cutoff value of 40% [AUC, 0.99 {95% CI: 0.97, 1.00}; Postcontrast myocardium-to-lumen R1 ratio showed excellent diagnostic performance comparable to that of MRI ECV in the detection of cardiac amyloidosis.

Identifiants

DOI: 10.1148/ryct.220327 PMID: 37124644 PMC: PMC10141336
pubmed: 37124644
doi: 10.1148/ryct.220327
pmc: PMC10141336
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e220327

Informations de copyright

© 2023 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of conflicts of interest: M.K. Belongs to the endowed department at Kumamoto University funded by donations from Philips Healthcare. S.O. No relevant relationships. S.T. No relevant relationships. Y.K. No relevant relationships. H.H. No relevant relationships. K.M. No relevant relationships. T.E. No relevant relationships. S.S. No relevant relationships. F.Y. No relevant relationships. T.N. No relevant relationships. Y.N. No relevant relationships. M.M. No relevant relationships. M.U. Research grants from Pfizer and Alnylam Pharmaceuticals; honoraria for lectures from Pfizer and Alnylam Pharmaceuticals. K.T. No relevant relationships. T.H. Research support from Philips Healthcare.

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Auteurs

Masafumi Kidoh (M)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-9589-7054

Seitaro Oda (S)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0003-4101-5113

Seiji Takashio (S)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-6201-0701

Yawara Kawano (Y)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-8269-440X

Hidetaka Hayashi (H)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-8082-2842

Kosuke Morita (K)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-0163-5564

Takafumi Emoto (T)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-3258-4085

Shinsuke Shigematsu (S)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0001-6753-6473

Fumihiro Yoshimura (F)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0001-9277-2988

Takeshi Nakaura (T)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-9010-0341

Yasunori Nagayama (Y)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0003-3280-7346

Masao Matsuoka (M)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-0473-754X

Mitsuharu Ueda (M)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-6814-0582

Kenichi Tsujita (K)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0002-4314-259X

Toshinori Hirai (T)

Department of Diagnostic Radiology (M.K., S.O., H.H., F.Y., T.N., Y.N., T.H.), Department of Cardiovascular Medicine (S.T., K.T.), Department of Hematology, Rheumatology, and Infectious Disease (Y.K., M.M.), and Department of Neurology (M.U.), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; and Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan (K.M., T.E., S.S.).
ORCID: 0000-0003-1480-2197

Classifications MeSH