A systematic assessment of photon-counting CT for bone mineral density and microarchitecture quantifications.
BMD
CT Quantifications
Computed Tomography
Microarchitecture
Osteoporosis
Photon-counting CT
Radiomics
Virtual imaging trials
Journal
Proceedings of SPIE--the International Society for Optical Engineering
ISSN: 0277-786X
Titre abrégé: Proc SPIE Int Soc Opt Eng
Pays: United States
ID NLM: 101524122
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pmc-release:
01
02
2024
medline:
1
5
2023
pubmed:
1
5
2023
entrez:
1
5
2023
Statut:
ppublish
Résumé
Photon-counting CT (PCCT) is an emerging imaging technology with potential improvements in quantification and rendition of micro-structures due to its smaller detector sizes. The aim of this study was to assess the performance of a new PCCT scanner (NAEOTOM Alpha, Siemens) in quantifying clinically relevant bone imaging biomarkers for characterization of common bone diseases. We evaluated the ability of PCCT in quantifying microarchitecture in bones compared to conventional energy-integrating CT. The quantifications were done through virtual imaging trials, using a 50 percentile BMI male virtual patient, with a detailed model of trabecular bone with varied bone densities in the lumbar spine. The virtual patient was imaged using a validated CT simulator (DukeSim) at CTDI
Identifiants
pubmed: 37125263
pmc: PMC10142096
mid: NIHMS1893891
pii:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB028744
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB001838
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155293
Pays : United States
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