Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.

Humans Male Female Thyroid Nodule / epidemiology Cross-Sectional Studies Pandemics Retrospective Studies Lymphatic Metastasis COVID-19 / epidemiology Thyroid Neoplasms / epidemiology

Journal

The lancet. Diabetes & endocrinology

ISSN: 2213-8595

Titre abrégé: Lancet Diabetes Endocrinol

Pays: England

ID NLM: 101618821

Informations de publication

Date de publication:
06 2023

Historique:

received: 02 01 2023

revised: 02 03 2023

accepted: 15 03 2023

medline: 29 5 2023

pubmed: 2 5 2023

entrez: 1 5 2023

Statut: ppublish

Résumé

Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation. None.

Sections du résumé

BACKGROUND

METHODS

In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186.

FINDINGS

Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039).

INTERPRETATION

Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.

FUNDING

None.

Identifiants

DOI: 10.1016/S2213-8587(23)00094-3 PMID: 37127041 PMC: PMC10147315

pubmed: 37127041

pii: S2213-8587(23)00094-3

doi: 10.1016/S2213-8587(23)00094-3

pmc: PMC10147315

pii:

doi:

Banques de données

ClinicalTrials.gov

['NCT05178186']

Types de publication

Multicenter Study Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

402-413

Investigateurs

A Abdallah (A)

A L Abentroth (AL)

V Acheimastos (V)

M Agunaoun (M)

H M Al Bisher (HM)

A Al Ghuzlan (A)

H Alakus (H)

M Alkan (M)

M C Almaraz Almaraz (MC)

K Amram (K)

S Anesidis (S)

E Anestiadou (E)

D Angelucci (D)

G L Ansaldo (GL)

M I Antonopoulou (MI)

M Arciniegas (M)

C Armellin (C)

G Arredondo Saldaña (G)

J Astl (J)

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H Aydın (H)

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J Babala (J)

M V Banús (MV)

L A Barba-Valadez (LA)

S V Barcons (SV)

F Battafarano (F)

A Bayat (A)

Rmc Bella (R)

F Benariba (F)

S Bernardi (S)

E G Bignami (EG)

M Bitenc (M)

S Bitsianis (S)

Jdd Bolaños de la Torre (J)

E Bonati (E)

T Bonetti (T)

F A Borges (FA)

K Bouchagier (K)

M Boudina (M)

A Bourial (A)

I Breuskin (I)

P Brock (P)

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T Burton (T)

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D Buzanakov (D)

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Type : CommentIn

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Informations de copyright

Déclaration de conflit d'intérêts

Declaration of interests We declare no competing interests.

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