Repositioning Cannabinoids and Terpenes as Novel EGFR-TKIs Candidates for Targeted Therapy Against Cancer: A virtual screening model using CADD and biophysical simulations.

Breast & Lung Cancer CADD Cannabinoids & Terpenes Cannabis sativa L. EGFR-TKIs MM-GBSA free Binding energy Molecular Dynamics Semi-flexible & Flexible Molecular Docking The inhibition constant (Ki) Virtual Screening

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
Apr 2023
Historique:
received: 05 12 2022
revised: 07 04 2023
accepted: 13 04 2023
medline: 2 5 2023
pubmed: 2 5 2023
entrez: 2 5 2023
Statut: epublish

Résumé

This study examines the potential of

Identifiants

pubmed: 37128337
doi: 10.1016/j.heliyon.2023.e15545
pii: S2405-8440(23)02752-4
pmc: PMC10148140
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e15545

Informations de copyright

© 2023 The Authors. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

The authors reported in the manuscript has no any conflict of interest.

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Auteurs

Ossama Daoui (O)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, P.O. Box 72, Fez, Morocco.

Suraj N Mali (SN)

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, India, 835215.

Kaouakeb Elkhattabi (K)

Department of Fundamental Sciences, Faculty of Dental Medicine, Mohammed V University in Rabat, Morocco.

Souad Elkhattabi (S)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, P.O. Box 72, Fez, Morocco.

Samir Chtita (S)

Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, P.O. Box 7955, Casablanca, Morocco.

Classifications MeSH