Multi-objective Symbolic Regression to Generate Data-driven, Non-fixed Structure and Intelligible Mortality Predictors using EHR: Binary Classification Methodology and Comparison with State-of-the-art.
Journal
AMIA ... Annual Symposium proceedings. AMIA Symposium
ISSN: 1942-597X
Titre abrégé: AMIA Annu Symp Proc
Pays: United States
ID NLM: 101209213
Informations de publication
Date de publication:
2022
2022
Historique:
medline:
3
5
2023
pubmed:
2
5
2023
entrez:
2
5
2023
Statut:
epublish
Résumé
Symbolic Regression (SR) is a data-driven methodology based on Genetic Programming, and it is widely used to produce arithmetic expressions for modelling learning tasks. Compared to other popular statistical techniques, SR outcomes are given by an arbitrary set of mathematical operations, representing arbitrarily complex linear and non-linear functions without a predefined fixed structure. Another advantage is that, unlike other machine learning algorithms, SR produces interpretable results. In this paper, we explore the qualities and limitations of this technique in a novel implementation as a binary classifier for in-hospital or short-term mortality prediction in patients with Covid-19. Our results highlight that SR provides a competitive alternative to popular statistical and machine learning methodologies to model relevant clinical phenomena thanks to good classification performance, stability in unbalanced dataset management, and intrinsic interpretability.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
442-451Subventions
Organisme : Department of Health
ID : RJ112/N027
Pays : United Kingdom
Informations de copyright
©2022 AMIA - All rights reserved.
Références
BMC Med Inform Decis Mak. 2022 Jul 25;22(1):196
pubmed: 35879758
Int J Epidemiol. 2021 Jan 23;49(6):1918-1929
pubmed: 32997743
PLoS One. 2018 Sep 4;13(9):e0202685
pubmed: 30180175
J Med Syst. 2017 Aug 8;41(9):142
pubmed: 28791547
Neural Comput. 2014 Jan;26(1):185-207
pubmed: 24102126
BMJ. 2020 Apr 7;369:m1328
pubmed: 32265220
Artif Intell Med. 2014 Mar;60(3):197-219
pubmed: 24525210
Bioinformatics. 2019 Jul 15;35(14):i427-i435
pubmed: 31510671
JAMA. 1993 Dec 22-29;270(24):2957-63
pubmed: 8254858
Crit Care Med. 2006 May;34(5):1297-310
pubmed: 16540951
J Biomed Inform. 2007 Dec;40(6):649-60
pubmed: 17485242
Clin Infect Dis. 2020 Nov 19;71(16):2079-2088
pubmed: 32361723
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32474598
BMJ. 2022 Jul 12;378:e069881
pubmed: 35820692
BMJ. 2020 Sep 9;370:m3339
pubmed: 32907855
IEEE J Biomed Health Inform. 2020 Nov;24(11):3103-3110
pubmed: 31871002