Probiotics, prebiotics, and synbiotics in nonalcoholic fatty liver disease and alcohol-associated liver disease.
NAFLD
alcohol-associated liver disease
gut barrier
gut microbiome
microbiota
Journal
American journal of physiology. Gastrointestinal and liver physiology
ISSN: 1522-1547
Titre abrégé: Am J Physiol Gastrointest Liver Physiol
Pays: United States
ID NLM: 100901227
Informations de publication
Date de publication:
01 07 2023
01 07 2023
Historique:
pmc-release:
01
07
2024
medline:
29
6
2023
pubmed:
2
5
2023
entrez:
2
5
2023
Statut:
ppublish
Résumé
The use of probiotics, prebiotics, and synbiotics has become an important therapy in numerous gastrointestinal diseases in recent years. Modifying the gut microbiota, this therapeutic approach helps to restore a healthy microbiome. Nonalcoholic fatty liver disease and alcohol-associated liver disease are among the leading causes of chronic liver disease worldwide. A disrupted intestinal barrier, microbial translocation, and an altered gut microbiome metabolism, or metabolome, are crucial in the pathogenesis of these chronic liver diseases. As pro-, pre-, and synbiotics modulate these targets, they were identified as possible new treatment options for liver disease. In this review, we highlight the current findings on clinical and mechanistic effects of this therapeutic approach in nonalcoholic fatty liver disease and alcohol-associated liver disease.
Identifiants
pubmed: 37129252
doi: 10.1152/ajpgi.00017.2023
pmc: PMC10312326
doi:
Substances chimiques
Prebiotics
0
Banques de données
figshare
['10.6084/m9.figshare.22701442.v3']
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
G42-G61Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001444
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Références
J Proteome Res. 2015 Feb 6;14(2):1174-82
pubmed: 25592873
Hepatology. 2013 Jul;58(1):108-19
pubmed: 23408358
Nutrients. 2019 Sep 03;11(9):
pubmed: 31484323
Alcohol Clin Exp Res. 2009 Oct;33(10):1836-46
pubmed: 19645728
J Gastroenterol Hepatol. 2013 Mar;28(3):450-5
pubmed: 23216382
J Gastroenterol Hepatol. 2018 Jan;33(1):70-85
pubmed: 28670712
PLoS One. 2013 Nov 20;8(11):e80604
pubmed: 24278294
Compr Physiol. 2013 Jul;3(3):1191-212
pubmed: 23897684
J Hepatol. 2018 Aug;69(2):396-405
pubmed: 29654817
Clin Liver Dis (Hoboken). 2018 Jan;11(1):11-15
pubmed: 29629177
Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G32-41
pubmed: 22538402
Exp Ther Med. 2019 Dec;18(6):4733-4739
pubmed: 31777560
J Proteome Res. 2013 Jul 5;12(7):3297-306
pubmed: 23763674
Gastroenterology. 2018 Aug;155(2):458-468.e8
pubmed: 29738698
Front Microbiol. 2022 Jul 22;13:920277
pubmed: 35935188
Medicine (Baltimore). 2023 Jan 27;102(4):e32734
pubmed: 36705359
J Microbiol Methods. 2011 Jul;86(1):42-51
pubmed: 21457733
Hepatology. 2012 Jul;56(1):118-29
pubmed: 22290395
Front Nutr. 2022 May 24;9:846873
pubmed: 35685888
Hepatol Commun. 2022 Aug;6(8):2058-2069
pubmed: 35368152
Chin Med J (Engl). 2020 Aug 5;133(15):1844-1855
pubmed: 32604176
Dig Dis. 2017;35(3):246-250
pubmed: 28249261
Nutrients. 2019 Jan 05;11(1):
pubmed: 30621265
Gut. 2019 Aug;68(8):1417-1429
pubmed: 30782617
J Lipid Res. 2020 Mar;61(3):269-271
pubmed: 31964761
Hepatology. 2015 Sep;62(3):762-72
pubmed: 25761863
Arch Med Sci. 2019 Sep;15(5):1336-1344
pubmed: 31572482
Nutr Metab Cardiovasc Dis. 2020 Oct 30;30(11):2103-2110
pubmed: 32807638
J Endocrinol. 2020 Jun;245(3):425-437
pubmed: 32302970
EMBO J. 2006 Apr 5;25(7):1419-25
pubmed: 16541101
Nutrients. 2022 Sep 24;14(19):
pubmed: 36235617
FASEB J. 2018 Jun 18;:fj201800351R
pubmed: 29912589
Biomed Res Int. 2018 Jan 16;2018:9340316
pubmed: 29682571
World J Gastroenterol. 2013 Mar 14;19(10):1527-40
pubmed: 23539674
N Engl J Med. 2009 Jun 25;360(26):2758-69
pubmed: 19553649
Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G563-G573
pubmed: 30767680
Front Nutr. 2022 Nov 21;9:1054265
pubmed: 36479298
PLoS One. 2018 Dec 26;13(12):e0209205
pubmed: 30586435
J Hepatol. 2022 Feb;76(2):332-342
pubmed: 34571050
Obesity (Silver Spring). 2019 Dec;27(12):2055-2066
pubmed: 31657148
Gastroenterology. 2000 Nov;119(5):1340-7
pubmed: 11054393
Eur J Gastroenterol Hepatol. 2018 Oct;30(10):1237-1246
pubmed: 30096092
Sci Rep. 2017 May 8;7(1):1529
pubmed: 28484247
Gastroenterology. 2014 May;146(6):1513-24
pubmed: 24440671
Dig Dis Sci. 2014 Mar;59(3):638-44
pubmed: 24323179
J Appl Toxicol. 2018 Oct;38(10):1323-1335
pubmed: 29785833
World J Clin Cases. 2020 Apr 26;8(8):1361-1384
pubmed: 32368530
J Dairy Sci. 2014 Dec;97(12):7386-93
pubmed: 25306266
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Hepatol Commun. 2017 Feb 27;1(1):53-60
pubmed: 29404433
J Lipid Res. 2015 Jun;56(6):1085-99
pubmed: 25210150
Hepatology. 2005 Jun;41(6):1313-21
pubmed: 15915461
Inflammopharmacology. 2018 Aug;26(4):1051-1055
pubmed: 29633106
Nat Rev Microbiol. 2022 Jun;20(6):365-380
pubmed: 34992261
Hepatology. 2017 May;65(5):1557-1565
pubmed: 28130788
Int J Mol Sci. 2020 Aug 16;21(16):
pubmed: 32824277
Front Cell Infect Microbiol. 2022 Jul 04;12:759306
pubmed: 35860380
FASEB J. 2013 Sep;27(9):3583-93
pubmed: 23709616
Hepatology. 2020 Oct;72(4):1191-1203
pubmed: 31953865
Clin Infect Dis. 2015 May 15;60 Suppl 2:S129-34
pubmed: 25922398
Gastroenterology. 2012 Nov;143(5):1330-1340.e1
pubmed: 22841787
Nat Med. 2022 Oct;28(10):2100-2106
pubmed: 36216942
Hepatogastroenterology. 1984 Feb;31(1):30-4
pubmed: 6698486
Gut. 2011 Feb;60(2):255-60
pubmed: 20940288
J Clin Exp Hepatol. 2022 Jul-Aug;12(4):1124-1132
pubmed: 35814513
Hepatology. 2017 Nov;66(5):1486-1501
pubmed: 28586172
Int Immunol. 2022 Sep 6;34(9):455-466
pubmed: 35792761
J Nutr. 2009 May;139(5):905-11
pubmed: 19321579
Hepatology. 2018 May;67(5):1726-1736
pubmed: 28941364
Hepatology. 2021 May;73(5):1688-1700
pubmed: 32750174
Int J Mol Sci. 2022 Aug 08;23(15):
pubmed: 35955942
Hepatology. 2015 Dec;62(6):1723-30
pubmed: 26274335
Nutrients. 2021 Sep 14;13(9):
pubmed: 34579068
Eur Rev Med Pharmacol Sci. 2011 Sep;15(9):1090-5
pubmed: 22013734
Hepatology. 2021 Feb;73(2):833-842
pubmed: 32780879
Gastroenterology. 2020 Nov;159(5):1839-1852
pubmed: 32652145
Gastroenterology. 2015 Aug;149(2):389-97.e10
pubmed: 25935633
Lancet Public Health. 2020 Jun;5(6):e316-e323
pubmed: 32504584
Appl Microbiol Biotechnol. 2020 Jun;104(12):5273-5282
pubmed: 32335723
J Gastroenterol Hepatol. 2020 Nov;35(11):1969-1977
pubmed: 32267559
Hepatology. 2001 Jul;34(1):101-8
pubmed: 11431739
Food Funct. 2018 Aug 15;9(8):4299-4309
pubmed: 30039147
Semin Liver Dis. 2021 Jan;41(1):87-102
pubmed: 33957682
Front Pharmacol. 2020 Nov 30;11:558525
pubmed: 33390939
Gut Microbes. 2020 Jul 3;11(4):882-899
pubmed: 31965894
Probiotics Antimicrob Proteins. 2019 Jun;11(2):335-347
pubmed: 29687200
J Food Sci. 2020 Oct;85(10):3611-3617
pubmed: 32885440
J Nutr Biochem. 2013 Sep;24(9):1609-15
pubmed: 23618528
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):895-911
pubmed: 29782919
Front Microbiol. 2022 Mar 03;12:796025
pubmed: 35310396
Gastroenterol Res Pract. 2010;2010:
pubmed: 20827314
JCI Insight. 2020 May 7;5(9):
pubmed: 32302292
Gut. 1982 May;23(5):362-70
pubmed: 7076013
Sci Rep. 2017 Mar 28;7:45176
pubmed: 28349964
Br J Nutr. 2014 Jul 14;112(1):1-7
pubmed: 24708895
Eur J Nutr. 2019 Jun;58(4):1735-1745
pubmed: 29779170
Food Funct. 2015 May;6(5):1692-700
pubmed: 25910227
Hepatol Int. 2022 Apr;16(2):359-370
pubmed: 35075592
Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1353-9
pubmed: 25244414
Gastroenterology. 2000 Dec;119(6):1637-48
pubmed: 11113085
J Hepatol. 2020 Mar;72(3):558-577
pubmed: 31622696
Metabolism. 2016 Aug;65(8):1038-48
pubmed: 26823198
Alcohol (Hanover). 2023 Jan;47(1):36-44
pubmed: 36446606
World J Gastroenterol. 2014 Jun 21;20(23):7381-91
pubmed: 24966608
J Hepatol. 1987 Feb;4(1):8-14
pubmed: 3571935
Gastroenterology. 2015 Jan;148(1):30-6
pubmed: 25447847
Alcohol. 2008 Dec;42(8):675-82
pubmed: 19038698
Am J Clin Nutr. 2014 Mar;99(3):535-42
pubmed: 24401715
Cells. 2021 Jun 14;10(6):
pubmed: 34198609
Int J Food Microbiol. 2008 Dec 10;128(2):371-7
pubmed: 18976829
Gut. 2019 Aug;68(8):1504-1515
pubmed: 30448775
Aliment Pharmacol Ther. 2014 Feb;39(3):254-69
pubmed: 24308774
Am J Pathol. 2011 Dec;179(6):2866-75
pubmed: 22093263
J Clin Gastroenterol. 2006 Mar;40(3):235-43
pubmed: 16633129
J Food Sci Technol. 2015 Dec;52(12):7577-87
pubmed: 26604335
Hepatobiliary Pancreat Dis Int. 2017 Aug 15;16(4):375-381
pubmed: 28823367
J Hepatol. 1995 Feb;22(2):165-72
pubmed: 7790704
Am J Gastroenterol. 2001 Apr;96(4):1200-4
pubmed: 11316170
Biomolecules. 2021 Aug 04;11(8):
pubmed: 34439821
Aliment Pharmacol Ther. 2012 Jun;35(11):1336-42
pubmed: 22490057
J Immunol Methods. 2015 Jun;421:44-53
pubmed: 25595554
Dig Liver Dis. 2014 Jun;46(6):556-60
pubmed: 24631029
Front Physiol. 2022 Apr 13;13:893074
pubmed: 35492588
Front Microbiol. 2020 Mar 26;11:512
pubmed: 32273874
Metabolism. 2011 Mar;60(3):404-13
pubmed: 20423748
Gastroenterology. 2020 Aug;159(2):639-651.e5
pubmed: 32169430
Clin Gastroenterol Hepatol. 2019 Apr;17(5):809-817
pubmed: 29378309
World J Gastroenterol. 2015 Mar 14;21(10):3072-84
pubmed: 25780308
Plant Foods Hum Nutr. 2013 Mar;68(1):18-23
pubmed: 23371785
Front Physiol. 2012 Oct 11;3:402
pubmed: 23087650
Gut. 2016 May;65(5):830-9
pubmed: 26642859
J Nutr. 1995 Jun;125(6):1401-12
pubmed: 7782892
J Clin Invest. 2017 Jun 30;127(7):2829-2841
pubmed: 28530644
EBioMedicine. 2022 Jun;80:104033
pubmed: 35490461
World J Gastroenterol. 2010 May 21;16(19):2435-9
pubmed: 20480532
J Biol Chem. 2015 Aug 28;290(35):21732-40
pubmed: 26187464
Alcohol Clin Exp Res. 2015 May;39(5):763-75
pubmed: 25872593
J Hepatol. 2022 Apr;76(4):788-799
pubmed: 34896404
Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G566-G582
pubmed: 29368944
Hepatology. 2011 Jan;53(1):96-105
pubmed: 21254165
Br J Surg. 2006 Aug;93(8):944-51
pubmed: 16823832
Aliment Pharmacol Ther. 2009 Jun 15;29(12):1273-81
pubmed: 19302262
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72
pubmed: 18931303
PLoS One. 2015 Feb 18;10(2):e0117451
pubmed: 25692549
Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G966-78
pubmed: 22241860
PLoS One. 2016 May 20;11(5):e0151829
pubmed: 27203081
BMC Gastroenterol. 2014 Feb 24;14:40
pubmed: 24564202
Nutrients. 2019 Dec 02;11(12):
pubmed: 31810197
Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G929-37
pubmed: 24699327
Gut. 2009 Aug;58(8):1091-103
pubmed: 19240062
J Immunol Res. 2021 Aug 17;2021:2264737
pubmed: 34458376
J Hepatol. 2008 Jun;48(6):945-51
pubmed: 18433921
Nature. 2019 Nov;575(7783):505-511
pubmed: 31723265
Elife. 2022 Jan 27;11:
pubmed: 35084335
PLoS One. 2015 Jan 28;10(1):e0116029
pubmed: 25629612
Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G911-8
pubmed: 24113768
BMJ Open Gastroenterol. 2019 Aug 07;6(1):e000315
pubmed: 31423319
Alcohol. 2009 Mar;43(2):163-72
pubmed: 19251117
BMC Microbiol. 2014 Sep 16;14:240
pubmed: 25223989
Nature. 2012 Sep 13;489(7415):220-30
pubmed: 22972295
Nutr Res Rev. 2004 Dec;17(2):259-75
pubmed: 19079930
Euroasian J Hepatogastroenterol. 2017 Jan-Jun;7(1):101-106
pubmed: 29201787
J Hepatol. 2011 Sep;55(3):654-659
pubmed: 21172393
Nat Rev Immunol. 2009 Nov;9(11):799-809
pubmed: 19855405
Sci Rep. 2015 Feb 03;5:8096
pubmed: 25644696
Ann Hepatol. 2013 Mar-Apr;12(2):256-62
pubmed: 23396737
Nat Med. 2019 May;25(5):716-729
pubmed: 31061539
Diabetes. 2015 Jul;64(7):2398-408
pubmed: 25695945
Hepatology. 2018 Jun;67(6):2150-2166
pubmed: 29159825
Gastroenterology. 2019 Apr;156(5):1264-1281.e4
pubmed: 30660725
J Hepatol. 2007 Oct;47(4):571-9
pubmed: 17644211
Toxicol Lett. 2015 May 5;234(3):194-200
pubmed: 25746479
BMC Gastroenterol. 2013 Oct 20;13:151
pubmed: 24138544
PLoS One. 2013;8(1):e53028
pubmed: 23326376
J Hepatol. 2000 May;32(5):742-7
pubmed: 10845660
Gastroenterology. 2020 May;158(6):1597-1610.e7
pubmed: 31987796
Mol Nutr Food Res. 2019 Sep;63(17):e1900257
pubmed: 31095863
Gastroenterology. 2020 May;158(6):1822-1830
pubmed: 32006545
Trends Immunol. 2013 Sep;34(9):446-52
pubmed: 23668977
Front Physiol. 2021 Jul 19;12:699253
pubmed: 34349667
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502
pubmed: 28611480
Gut. 2021 Jul;70(7):1299-1308
pubmed: 33004548
Nutrients. 2017 Oct 16;9(10):
pubmed: 29035308
Lancet Gastroenterol Hepatol. 2023 Jun;8(6):523-532
pubmed: 36893774
Sci Rep. 2021 Feb 4;11(1):3030
pubmed: 33542369
Clin Chim Acta. 1983 Feb 7;127(3):373-82
pubmed: 6839491
Hepatology. 2009 Jan;49(1):97-105
pubmed: 19053048
Intern Med. 2012;51(16):2151-5
pubmed: 22892494
PLoS One. 2014 Jan 27;9(1):e80169
pubmed: 24475018
Hepatology. 2012 Jun;55(6):2005-23
pubmed: 22488764
Hepatol Commun. 2020 Jun 19;4(8):1168-1182
pubmed: 32766476
Cell Mol Gastroenterol Hepatol. 2015 Mar;1(2):222-232
pubmed: 26405687
Nutrients. 2016 Jun 28;8(7):
pubmed: 27367724
Hepatology. 2022 Jan;75(1):219-228
pubmed: 34537988
Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G881-4
pubmed: 15132946
Gut. 2012 Jul;61(7):1058-67
pubmed: 22253482
Dig Dis Sci. 2012 Feb;57(2):545-53
pubmed: 21901256
J Clin Gastroenterol. 2005 Jul;39(6):540-3
pubmed: 15942443
Eur J Gastroenterol Hepatol. 2015 Nov;27(11):1300-6
pubmed: 26302024
Hepatology. 2009 Jun;49(6):1877-87
pubmed: 19291785
Cell Metab. 2019 Oct 1;30(4):675-688.e7
pubmed: 31543403
Eur J Clin Nutr. 2021 Aug;75(8):1227-1236
pubmed: 33514869
Prog Mol Biol Transl Sci. 2020;176:1-42
pubmed: 33814111
Nat Med. 2015 Feb;21(2):159-65
pubmed: 25559344
Front Immunol. 2021 Jun 11;12:678360
pubmed: 34177920
Alcohol Alcohol. 2004 Jul-Aug;39(4):336-9
pubmed: 15208167
World J Gastroenterol. 2018 Aug 14;24(30):3361-3373
pubmed: 30122876
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
Hepatology. 2020 Dec;72(6):2182-2196
pubmed: 32654263
Dig Dis Sci. 2012 Jul;57(7):1932-41
pubmed: 22427130
Sci Rep. 2016 Jan 08;6:19032
pubmed: 26742586
J Microbiol Biotechnol. 2017 Aug 28;27(8):1491-1499
pubmed: 28511293
J Hepatol. 1991 Mar;12(2):162-9
pubmed: 2050995
Nat Rev Gastroenterol Hepatol. 2015 May;12(5):303-10
pubmed: 25824997
J Hepatol. 2014 May;60(5):940-7
pubmed: 24374295
Front Nutr. 2022 Oct 25;9:1024678
pubmed: 36386939
J Inflamm (Lond). 2010 Mar 30;7:15
pubmed: 20353583
Sci Rep. 2016 Jan 08;6:19076
pubmed: 26743949
Am J Gastroenterol. 2014 Oct;109(10):1547-61; quiz 1546, 1562
pubmed: 25070051
Hepatology. 2018 Jan;67(1):145-158
pubmed: 28802074
Front Microbiol. 2019 Oct 23;10:2407
pubmed: 31708888
Hepatology. 2013 Feb;57(2):601-9
pubmed: 23055155
Gastroenterology. 2006 Oct;131(4):1057-63
pubmed: 17030176
Hepatol Int. 2013 Jun;7(2):767-74
pubmed: 26201812
Front Nutr. 2022 May 20;9:880014
pubmed: 35669067
FEMS Microbiol Lett. 2019 Jul 1;366(13):
pubmed: 31295342
J Dig Dis. 2017 Dec;18(12):698-703
pubmed: 29148175
Sci Rep. 2020 Oct 30;10(1):18768
pubmed: 33127939
Hepatology. 2009 Mar;49(3):989-97
pubmed: 19115316
Hepatology. 2003 Mar;37(3):551-7
pubmed: 12601352
Gut Microbes. 2020 Nov 9;12(1):1782157
pubmed: 32588725
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
pubmed: 24912386
PLoS One. 2018 Dec 31;13(12):e0210120
pubmed: 30596786
Gut. 2004 Jan;53(1):108-14
pubmed: 14684584
Dig Dis Sci. 2016 May;61(5):1356-64
pubmed: 27017224
Gastroenterol Res Pract. 2016;2016:5491465
pubmed: 26839540
J Hepatol. 2023 Apr;78(4):836-851
pubmed: 36565724
J Clin Oncol. 2011 Aug 10;29(23):3140-5
pubmed: 21730269
Liver Transpl. 2020 Jan;26(1):141-159
pubmed: 31610081
JAMA. 2012 May 9;307(18):1959-69
pubmed: 22570464
Proc Soc Exp Biol Med. 1994 Mar;205(3):243-7
pubmed: 8171045
Hepatology. 2012 Nov;56(5):1751-9
pubmed: 22707395
Hepatology. 2009 Oct;50(4):1094-104
pubmed: 19637282
J Clin Biochem Nutr. 2012 Jan;50(1):72-7
pubmed: 22247604
Sci Rep. 2019 Apr 5;9(1):5688
pubmed: 30952918
Hepatology. 2011 Sep 2;54(3):1082-1090
pubmed: 21618575
Hepatology. 2016 Mar;63(3):764-75
pubmed: 26600078
Semin Immunopathol. 2021 Aug;43(4):577-590
pubmed: 34236487
Food Funct. 2020 Nov 18;11(11):9903-9911
pubmed: 33094788