[The most privy of all privy councilors in the Russian Empire: To the biography of Vyacheslav Avksentievich Manassein (1841-1901)].

The article, on the basis of archival documents introduced into scientific circulation, considers personality of prominent Russian physician Vyacheslav Avksentievich Manassein (1841-1901), who held the position of professor of the therapeutic Chairs of the Medical Surgical Academy in 1875-1892. The Manassein's public activity had special character, reaching All-Russian scale owing to the weekly "The Physician" published by him in 1880-1901. The article considers various aspects related to the scientific school of S. P. Botkin. For the first time, it is reported about the facts shedding light on complicated relationship of S. P. Botkin with his student V. A. Manassein.