A novel injectable radiopaque hydrogel with potent properties for multicolor CT imaging in the context of brain and cartilage regenerative therapy.

Hyaluronic acid bicolor X-ray imaging techniques cell therapy injectable hydrogel iodine contrast agent

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
21 Apr 2023
Historique:
pubmed: 3 5 2023
medline: 3 5 2023
entrez: 3 5 2023
Statut: epublish

Résumé

Cell therapy is promising to treat many conditions, including neurological and osteoarticular diseases. Encapsulation of cells within hydrogels facilitates cell delivery and can improve therapeutic effects. However, much work remains to be done to align treatment strategies with specific diseases. The development of imaging tools that enable monitoring cells and hydrogel independently is key to achieving this goal. Our objective herein is to longitudinally study an iodine-labeled hydrogel, incorporating gold-labeled stem cells, by bicolor CT imaging after

Identifiants

pubmed: 37131613
doi: 10.1101/2023.04.20.537520
pmc: PMC10153246
pii:
doi:

Types de publication

Preprint

Langues

eng

Auteurs

Moustoifa Said (M)

Univ. Grenoble Alpes, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), 38041 Grenoble, France; Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Clément Tavakoli (C)

Univ. Lyon 1, Inserm U1060, CarMeN Laboratory, 69600 Oullins, France; Univ. Grenoble Alpes, Inserm, UA7 Strobe, 38000 Grenoble, France.

Chloé Dumot (C)

Univ. Lyon 1, Inserm U1060, CarMeN Laboratory, 69600 Oullins, France.

Karine Toupet (K)

IRMB, Univ. Montpellier, INSERM, CHU Montpellier, Montpellier, France.

Yuxi Clara Dong (YC)

Department of Radiology and Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Nora Collomb (N)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Céline Auxenfans (C)

Hopital Edouard Herriot, Lyon, France.

Anaïck Moisan (A)

Cell Therapy and Engineering Unit, EFS Rhone Alpes, 38330 Saint Ismier, France.

Bertrand Favier (B)

Univ. Grenoble Alpes, Translational Innovation in Medicine & Complexity, UMR552, 38700 La Tronche, France.

Benoit Chovelon (B)

Univ. Grenoble-Alpes, Departement de Pharmacochimie Moleculaire UMR 5063, 38400 Grenoble, France; Institut de Biologie et Pathologie, CHU de Grenoble-Alpes, 38700 La Tronche, France.

Emmanuel Luc Barbier (EL)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Christian Jorgensen (C)

IRMB, Univ. Montpellier, INSERM, CHU Montpellier, Montpellier, France.

David Peter Cormode (DP)

Department of Radiology and Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Danièle Noël (D)

IRMB, Univ. Montpellier, INSERM, CHU Montpellier, Montpellier, France.

Emmanuel Brun (E)

Univ. Grenoble Alpes, Inserm, UA7 Strobe, 38000 Grenoble, France.

Hélène Elleaume (H)

Univ. Grenoble Alpes, Inserm, UA7 Strobe, 38000 Grenoble, France.

Marlène Wiart (M)

Univ. Lyon 1, Inserm U1060, CarMeN Laboratory, 69600 Oullins, France.

Olivier Detante (O)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France; CHU Grenoble Alpes, Stroke Unit, Department of Neurology, 38043 Grenoble, France.

Claire Rome (C)

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France.

Rachel Auzély-Velty (R)

Univ. Grenoble Alpes, Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), 38041 Grenoble, France.

Classifications MeSH