Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (


Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
17 Apr 2023
Historique:
medline: 3 5 2023
pubmed: 3 5 2023
entrez: 3 5 2023
Statut: epublish

Résumé

Deuterium metabolic imaging (DMI) and quantitative exchange label turnover (QELT) are novel MR spectroscopy techniques for non-invasive imaging of human brain glucose and neurotransmitter metabolism with high clinical potential. Following oral or intravenous administration of non-ionizing [6,6'- Five volunteers (4m/1f) were scanned in repeated sessions for 60 min after overnight fasting and 0.8g/kg oral [6,6'- One hour after oral tracer administration regionally averaged deuterium labeled Glx This study demonstrates that indirect detection of deuterium labeled compounds using

Identifiants

pubmed: 37131634
doi: 10.1101/2023.04.17.23288672
pmc: PMC10153308
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB031787
Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Fabian Niess (F)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.

Bernhard Strasser (B)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.

Lukas Hingerl (L)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.

Eva Niess (E)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK).

Stanislav Motyka (S)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK).

Gilbert Hangel (G)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Department of Neurosurgery, Medical University of Vienna.

Martin Krššák (M)

Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna.

Stephan Gruber (S)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK).

Benjamin Spurny-Dworak (B)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna.

Siegfried Trattnig (S)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Institute for Clinical Molecular MRI, Karl Landsteiner Society, 3100 St. Pölten, Austria.

Thomas Scherer (T)

Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna.

Rupert Lanzenberger (R)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna.

Wolfgang Bogner (W)

High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna.
Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK).

Classifications MeSH