Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
18 Apr 2023
18 Apr 2023
Historique:
pubmed:
3
5
2023
medline:
3
5
2023
entrez:
3
5
2023
Statut:
epublish
Résumé
Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders. A comprehensive understanding of DNA methylation diversity across the entire brain in the context of the brain's 3D spatial organization is essential for building a complete molecular atlas of brain cell types and understanding their gene regulatory landscapes. To this end, we employed optimized single-nucleus methylome (snmC-seq3) and multi-omic (snm3C-seq
Identifiants
pubmed: 37131654
doi: 10.1101/2023.04.16.536509
pmc: PMC10153407
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIH HHS
ID : S10 OD023689
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114830
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114831
Pays : United States
Déclaration de conflit d'intérêts
Competing Interests J.R.E serves on the scientific advisory board of Zymo Research Inc. B.R. is a shareholder of Arima Genomics Inc., and Epigenome Technologies, Inc. H.Z. is on the scientific advisory board of MapLight Therapeutics, Inc
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