Conserved enhancer logic controls the notochord expression of vertebrate

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
20 Apr 2023
Historique:
pubmed: 3 5 2023
medline: 3 5 2023
entrez: 3 5 2023
Statut: epublish

Résumé

The cell type-specific expression of key transcription factors is central to development. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the mammalian notochord has remained elusive. Here, we identify the complement of notochord-specific enhancers in the mammalian

Identifiants

DOI: 10.1101/2023.04.20.536761 PMID: 37131681 PMC: PMC10153258
pubmed: 37131681
doi: 10.1101/2023.04.20.536761
pmc: PMC10153258
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG003988
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028599
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024745
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL162304
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK129350
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM141742
Pays : United States
Organisme : NHGRI NIH HHS
ID : DP2 HG010013
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL167580
Pays : United States

Commentaires et corrections

Type : UpdateIn

Déclaration de conflit d'intérêts

Competing financial interests The authors declare no competing financial interests.

Auteurs

Cassie L Kemmler (CL)

Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Jana Smolikova (J)

Institute of Molecular Genetics of the ASCR, v. v. i., Prague, Czech Republic.

Hannah R Moran (HR)

Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Brandon J Mannion (BJ)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.

Dunja Knapp (D)

Technische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.

Fabian Lim (F)

Department of Medicine, Health Sciences, University of California San Diego, La Jolla, CA, USA.
Department of Molecular Biology, Biological Sciences, University of California San Diego, La Jolla, CA USA.
Biological Sciences Graduate Program, University of California San Diego, La Jolla, CA, USA.

Anna Czarkwiani (A)

Technische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.

Viviana Hermosilla Aguayo (V)

Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.
Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.

Vincent Rapp (V)

Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

Olivia E Fitch (OE)

Department of Integrative Biology and Ecology, Evolution and Behavior Program, Michigan State University, East Lansing, MI, USA.

Seraina Bötschi (S)

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

Licia Selleri (L)

Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, USA.
Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.
Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.
Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.

Emma Farley (E)

Department of Medicine, Health Sciences, University of California San Diego, La Jolla, CA, USA.
Department of Molecular Biology, Biological Sciences, University of California San Diego, La Jolla, CA USA.

Ingo Braasch (I)

Department of Integrative Biology and Ecology, Evolution and Behavior Program, Michigan State University, East Lansing, MI, USA.

Maximina Yun (M)

Technische Universität Dresden, CRTD/Center for Regenerative Therapies Dresden, Dresden, Germany.
Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.
Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany.

Axel Visel (A)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
School of Natural Sciences, University of California Merced, Merced, CA, USA.

Marco Osterwalder (M)

Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.
Department of Cardiology, Berne University Hospital, Berne, Switzerland.

Christian Mosimann (C)

Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Zbynek Kozmik (Z)

Institute of Molecular Genetics of the ASCR, v. v. i., Prague, Czech Republic.

Alexa Burger (A)

Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Classifications MeSH